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FAM90A1 and EFEMP2
Data Source:
BioGRID
(two hybrid)
FAM90A1
EFEMP2
Description
family with sequence similarity 90 member A1
EGF containing fibulin extracellular matrix protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
Protein Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Gut microbiota (functional units) (
27694959
)
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
162 interacting genes:
ABI2
ACTN3
AKAP9
AMOTL2
ANKRD23
ANKRD29
AP2M1
APP
ARHGEF9
ARRDC3
BANP
BCAR1
BEGAIN
BHLHB9
BLZF1
CADPS
CALCOCO2
CARD9
CCDC13
CCDC57
CCN3
CCNC
CCNL2
CDR2
CEP55
CEP70
CEP72
CEP76
CHRDL2
COG6
CYSRT1
DTX3
DVL2
DVL3
EFEMP2
ENKD1
EXOSC8
FAM228A
FHL3
FLACC1
FLOT1
FOSB
FSD2
FXR1
FXR2
FYN
GABPB1
GCSAML
GNPTAB
GOLGA2
GOPC
GPSM1
GRIPAP1
HAND2
HMBOX1
HOMER3
HOMEZ
HOOK2
HSF2BP
ISY1
KANK2
KASH5
KIFC3
KLHL12
KPNA3
KPNA6
KRT31
KRT34
KRT38
KRT40
KRTAP1-1
KRTAP10-8
LDOC1
LHX6
LIMS1
LMO2
LNX1
LRP2BP
LRRK2
LZTS1
LZTS2
MAD1L1
MDFI
MEIS3
MID2
MIPOL1
MLH1
MORN3
MSS51
MTUS2
MYOG
NBPF19
NDUFB7
NOTCH2NLA
NUDT21
OVOL1
PBX1
PBX2
PDLIM7
PFDN5
PICK1
PIH1D1
PLAGL2
POF1B
PPARA
PPP1R13B
PRDM6
PRKAR1B
PRR23B
PSME3
PSTPIP1
RAB11FIP2
RABEP1
RBM48
REL
RHOH
RINT1
ROPN1
RPRD1A
SH2B2
SIAH1
SMAD3
SMARCB1
SNW1
SPRED1
SRPK2
STAC3
STMN2
STX11
TAX1BP1
TEPSIN
TFIP11
TLE5
TMCC2
TRAF2
TRAF4
TRIB3
TRIM23
TRIM27
TRIM42
TRIM54
TRIM55
TRIM69
TRIM9
TRIML2
VRTN
VWC2
ZBTB14
ZBTB16
ZBTB7B
ZBTB8A
ZC2HC1C
ZMYND12
ZNF143
ZNF212
ZNF343
ZNF526
ZNF581
ZNF655
ZNF688
ZNF76
ZWINT
130 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
55138
30008
HPRD ID
07672
05221
Ensembl ID
ENSG00000171847
ENSG00000172638
Uniprot IDs
Q86YD7
A0A024R5G1
O95967
Q9H3D5
PDB IDs
2KL7
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Intersection)
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