CEP192 and SHBG

Data Source:
HPRD (two hybrid)

		CEP192	SHBG
Description		centrosomal protein 192	sex hormone binding globulin
Image
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol	Extracellular Region Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Phosphatase Binding	Steroid Binding Androgen Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Response To Bacterium Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphatase Activity Centrosome Duplication Protein Localization To Centrosome Centrosome-templated Microtubule Nucleation Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS		Appendicular lean mass ( 33097823) General cognitive ability ( 29844566)	Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266)
Interacting Genes		3 interacting genes: LINC00839 SHBG UBC	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 C9orf24 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		55125	6462
HPRD ID		10855	01646
Ensembl ID		ENSG00000101639	ENSG00000129214
Uniprot IDs		Q8TEP8 Q9HCK3	B0FWH2 B0FWH8 B4DYU0 I3L145 P04278
PDB IDs		4N7Z 6FVI 6W3J	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?
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