AVP and AVPR1B

Data Source:
HPRD (in vivo)

		AVP	AVPR1B
Description		arginine vasopressin	arginine vasopressin receptor 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Vesicle Membrane	Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Peptide Binding
	Biological Process	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Membrane Organization ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria	Regulation Of Systemic Arterial Blood Pressure By Vasopressin G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase A2 Activity Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Arachidonic Acid Secretion Transport Across Blood-brain Barrier
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Transport of organic anions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production	Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Drugs			Desmopressin Vasopressin Terlipressin PH-284 SR 121463 Atosiban Lypressin
Diseases		Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS
Interacting Genes		9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17	2 interacting genes: AVP GRK5
Entrez ID		551	553
HPRD ID		01891	02600
Ensembl ID		ENSG00000101200	ENSG00000198049
Uniprot IDs		P01185 X5DQP6	P47901
PDB IDs
Enriched GO Terms of Interacting Partners?
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