NRDE2 and VPS28

Data Source:
BioGRID (two hybrid)

		NRDE2	VPS28
Description		NRDE-2, necessary for RNA interference, domain containing	VPS28 subunit of ESCRT-I
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Nuclear Speck	ESCRT I Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Late Endosome Membrane Host Cell Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	Protein Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	RNA Interference Heterochromatin Assembly By Small RNA Positive Regulation Of RNA Export From Nucleus Negative Regulation Of RNA Catabolic Process	Endosomal Transport Macroautophagy Viral Life Cycle Negative Regulation Of Protein Ubiquitination Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Intracellular Transport Of Virus Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways			Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Lifespan ( 25918517) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Blood metabolite levels ( 26401656) Educational attainment ( 25201988)
Interacting Genes		11 interacting genes: ARFIP2 CCDC183 HAUS8 ITGB3BP LHX3 MED29 MESD RCOR3 SPG21 UQCC2 VPS28	45 interacting genes: ABI2 ASF1A BEX2 BLZF1 CARD9 CBX5 CCDC146 CDK18 CEP57L1 COX5B FABP3 GABARAP GEM GLCCI1 GOLGA2 INCA1 LMO3 MBIP NRDE2 NXF1 PDCD6IP PNMA5 PRKAA2 PRKAB2 RASSF5 SAXO1 SHC3 SKIL SMN1 SMN2 SUOX TCF12 TCF4 TRIM27 TRIM54 TSG101 TSNAX UBA52 UBC USHBP1 USP2 VPS37A VPS37B VPS37C VPS52
Entrez ID		55051	51160
HPRD ID		12625	11675
Ensembl ID		ENSG00000119720	ENSG00000160948
Uniprot IDs		Q9H7Z3	A0A0S2Z5H5 Q548N1 Q9UK41
PDB IDs		6IEH	6VME
Enriched GO Terms of Interacting Partners?
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