HERC6 and NME2

Data Source:
BioGRID (two hybrid)

		HERC6	NME2
Description		HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	NME/NM23 nucleoside diphosphate kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Intermediate Filament Focal Adhesion Lamellipodium Mitochondrial Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity	DNA Binding Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Serine/threonine Kinase Activity Fatty Acid Binding Protein Binding ATP Binding Drug Binding GDP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding
	Biological Process	Protein Polyubiquitination	Negative Regulation Of Myeloid Leukocyte Differentiation Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Positive Regulation Of Neuron Projection Development Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Cellular Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Response To Growth Hormone Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interconversion of nucleotide di- and triphosphates Neutrophil degranulation
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Lean body mass ( 28552196) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)
Interacting Genes		4 interacting genes: HERC3 HERC4 NME2 UBE2L3	18 interacting genes: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM
Entrez ID		55008	4831
HPRD ID		13647	01132
Ensembl ID		ENSG00000138642	ENSG00000243678
Uniprot IDs		Q8IVU3	F6XY72 P22392 Q6FHN3
PDB IDs		5W87	1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?
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