SEMA4C and GIPC1

Data Source:
HPRD (in vitro, in vivo)

		SEMA4C	GIPC1
Description		semaphorin 4C	GIPC PDZ domain containing family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Postsynaptic Density Synaptic Vesicle Membrane Postsynaptic Density Membrane	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Identical Protein Binding Cadherin Binding
	Biological Process	Neural Crest Cell Migration Neural Tube Closure Axon Guidance Cell Migration In Hindbrain Cerebellum Development Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Muscle Cell Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Regulation Of Synaptic Vesicle Exocytosis
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Kidney stones ( 31729369)
Interacting Genes		20 interacting genes: CYSRT1 DLG1 DLG2 DLG3 DLG4 GIPC1 HSF2BP KRT16 KRT27 KRT31 KRT34 KRT40 KRTAP6-3 NBPF19 NCDN NOTCH2NLA PNMA1 RCHY1 TRIM54 USHBP1	36 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SH3BP4 SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408
Entrez ID		54910	10755
HPRD ID		07257	05462
Ensembl ID		ENSG00000168758	ENSG00000123159
Uniprot IDs		Q9C0C4	A0A024R7I0 A0A024R7I1 A8K2I7 O14908
PDB IDs		6N5Z
Enriched GO Terms of Interacting Partners?
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