PPIB and HSPA6

Data Source:
BioGRID (two hybrid)

		PPIB	HSPA6
Description		peptidylprolyl isomerase B	heat shock protein family A (Hsp70) member 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Membrane Protein-containing Complex Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Cyclosporin A Binding Unfolded Protein Binding RNA Polymerase Binding	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Neutrophil Chemotaxis Positive Regulation Of Multicellular Organism Growth Positive Regulation By Host Of Viral Process Positive Regulation By Host Of Viral Genome Replication Protein Stabilization Bone Development Chaperone-mediated Protein Folding Regulation Of Post-translational Protein Modification	Response To Unfolded Protein Vesicle-mediated Transport Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Neutrophil Degranulation Chaperone Cofactor-dependent Protein Refolding Cellular Heat Acclimation
Pathways		Collagen biosynthesis and modifying enzymes	Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs		Proline 1,4-Dithiothreitol
Diseases		Osteogenesis imperfecta
GWAS			Birth weight ( 31043758) Blood protein levels ( 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 28067908 23128233) Offspring birth weight ( 31043758) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		23 interacting genes: APOB ATP12A BANP CAMLG DNM2 ESR1 GLP1R H3-4 HSPA6 IRF3 MDM2 PEX19 PRH1 PRL SGTA SGTB STAT5A TP53 TRDN UBQLN1 UBQLN2 UBQLN4 VKORC1	16 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 TERF1
Entrez ID		5479	3310
HPRD ID		00458	00775
Ensembl ID		ENSG00000166794	ENSG00000173110
Uniprot IDs		P23284	A0A384NKX5 B3KSM6 P17066
PDB IDs		1CYN 3ICH 3ICI	3FE1
Enriched GO Terms of Interacting Partners?
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