POLR2K and FBXO7

Data Source:
BioGRID (enzymatic study)

		POLR2K	FBXO7
Description		RNA polymerase II, I and III subunit K	F-box protein 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex RNA Polymerase I Complex Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Neurite Lewy Body Core Lewy Body Corona
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Heterodimerization Activity Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription By RNA Polymerase III Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Positive Regulation Of Type I Interferon Production Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	Protein Polyubiquitination Autophagy Of Mitochondrion Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Regulation Of Neuron Projection Development Protein Ubiquitination Regulation Of Protein Stability Regulation Of Locomotion Post-translational Protein Modification Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Parkinson's disease (PD)
GWAS			Blood protein levels ( 29875488) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: APP BRCA1 FBXO7 POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J SH3KBP1 SMYD3	345 interacting genes: AATF ABCF3 ABL1 ACOT8 ACSL5 ACSM3 ACTC1 ACVR1 ACVR2B AK8 AKAP14 AKIRIN2 AKT3 ALKBH3 AMOTL2 ANGPTL7 ANKRD36BP1 ANP32E APEX1 APOBEC3C APOBEC4 ASPH ASPHD1 ATAT1 ATF5 ATP5F1C BAG3 BCKDK BIRC2 BLK BUB1 BUB1B C11orf16 C15orf48 C1orf105 C1orf115 C22orf31 C2orf88 CACYBP CAMK1 CAPN5 CASQ2 CCBE1 CCDC186 CCDC60 CCDC88C CCNE2 CDC34 CDK10 CDK14 CENPJ CEP112 CFAP300 CHCHD2 CHCHD6 CHMP2B CHMP3 CILK1 CIRBP CKAP2 CLHC1 CLIP3 CMTR2 CNOT7 COLEC12 CPEB4 CSNK1E CXCL12 CXCL9 DDRGK1 DDX10 DHRS2 DHX40 DNAH14 DNAJA3 DNAJB12 DNAJC30 DPY19L2P1 DRAP1 ELF4 EP400P1 EPHA3 EPHB2 EPHB3 EPHB4 ERBB2 ERICH2 FGF10 FGF13 FGFR1 FGFR2 FMOD FUT8 FYTTD1 GADD45GIP1 GAPDH GBP2 GEMIN2 GGA2 GLCE GLIPR2 GLRX2 GMCL2 GNLY GORAB GPAM GPKOW GRK6 GSK3B H1-0 H2AZ2 H3-3B HADH HMG20A HMG20B HMGB2 HMGCS2 HNRNPK HPF1 IDH2 IFT88 IGKV1-5 IL4 IL7 ILKAP INKA2 INPP5K INTS7 IPO9 IRF3 JADE2 KCNAB1 KCTD14 KHDRBS3 KIAA1586 KIF12 KIFC3 KIRREL3-AS3 KLF4 KMO KPNA5 LETMD1 LGALS3BP LIMK1 LIMK2 LINC01483 LMNA LRRC20 LRRC8E LRRFIP1 MAK MAP2K6 MAPK10 MAPK9 MAPRE2 MARK2 MARK3 MBD5 MBNL1 MCM2 MCM5 MDK MED22 MED27 MEF2D MEST MIR1-1HG-AS1 MIS18BP1 MITF MMP13 MMP8 MNDA MOB3A MOB3C MPG MPP3 MPZL1 MRM3 MRPL27 MRPS14 MTIF3 MTUS1 MYOG NANS NDE1 NFIA NFIC NKD2 NPHP1 NUDT16L1 NUMB NVL ODF2L OLFML2A OR14K1 ORC3 OSTF1 PABPC3 PACRG PAFAH1B1 PAK6 PCBD2 PDCD7 PDE12 PDE4D PDGFB PGAP4 PHLDA1 PIEZO1 PIGY PIM1 PIM2 PINK1 PLEKHA1 PNOC PNRC2 POLDIP2 POLR2K PPHLN1 PPP1CB PPP1R17 PPP1R21 PRAME PRICKLE2 PRKACB PRKCA PRKCB PRKCG PRKN PRMT1 PRRC2B PUF60 PUSL1 QKI RBBP6 RBM23 RBM33 RCC1 REEP3 REEP4 RET RGS1 RGS22 RNF121 RNF20 RORB RPL14 RPL26 RPL36A RPL37A RPL3L RPL6 RPS15A RPS18 RPS19BP1 RPS2 RPS6KA3 RPS6KB1 RSL24D1 RWDD4 S100A13 S100A16 S100B SAMHD1 SCARA5 SDCCAG8 SEC16B SEC24C SET SFR1 SHMT1 SHMT2 SKP1 SLAIN1 SLC25A26 SLC35B3 SLC7A6OS SMARCD1 SMOC2 SNAP25 SNRPA SNX33 SPATA4 SPDYA SPRY2 SRCIN1 SRPK3 SRSF10 SRSF7 SS18L2 STAT6 STYX TAF9B TARDBP TBC1D3P2 TBPL1 TC2N TCP10L3 TEAD4 TEC TECR TECRL TENT5D TEX29 TGIF2 THAP7 TLE3 TMED10 TMEM120A TMEM237 TMOD2 TMPRSS5 TOMM20 TRAPPC12 TRIB3 TRIM44 TSBP1 TSLP UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2M UROD USF1 USH1C UXS1 UXT VPS16 VRK3 WDR18 WDR24 XPO1 XRN1 YPEL5 ZBTB44 ZC2HC1C ZFYVE21 ZKSCAN8 ZMYM5 ZNF462 ZNF574 ZNF684 ZNF688
Entrez ID		5440	25793
HPRD ID		05826	07292
Ensembl ID		ENSG00000147669	ENSG00000100225
Uniprot IDs		A0A024R9G0 P53803	Q9Y3I1
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L	4L9C 4L9H
Enriched GO Terms of Interacting Partners?
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