POLR2B and POLR2L

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		POLR2B	POLR2L
Description		RNA polymerase II subunit B	RNA polymerase II, I and III subunit L
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm RNA Polymerase II, Core Complex Membrane	Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	RNA Polymerase II Activity DNA Binding Chromatin Binding RNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ribonucleoside Binding Metal Ion Binding	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase I Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Positive Regulation Of Type I Interferon Production Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Bitter alcoholic beverage consumption ( 31046077) Congenital heart disease (maternal effect) ( 28468790) Coronary artery disease ( 29212778) Height ( 20881960 25429064) Metabolite levels ( 23823483) White blood cell count ( 29403010)	Pulse pressure ( 30578418)
Interacting Genes		20 interacting genes: BTF3 CALM1 CCNH CDK7 CTDP1 IKBKG ITCH LZTR1 MEN1 NEDD4 OTUD5 POLR2C POLR2D POLR2H POLR2K POLR2L PTEN SNAR-B2 SUB1 ZSCAN1	28 interacting genes: AGR2 BANP CCDC85B CCN3 CHEK2 COIL EXOSC5 FAM217B L3MBTL3 NACC1 NFKBIB PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2G POLR2H PSMA6 REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 TRIP13 ZBTB14
Entrez ID		5431	5441
HPRD ID		15943	01155
Ensembl ID		ENSG00000047315	ENSG00000177700
Uniprot IDs		B4DH29 B4DHJ3 C9J2Y9 P30876	P62875
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L	5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L
Enriched GO Terms of Interacting Partners?
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