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SEPTIN5 and CDK5R1
Data Source:
BioGRID
(two hybrid, pull down)
SEPTIN5
CDK5R1
Description
septin 5
cyclin dependent kinase 5 regulatory subunit 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Septin Ring
Synaptic Vesicle
Microtubule Cytoskeleton
Septin Complex
Cell Division Site
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Perikaryon
Intracellular Membrane-bounded Organelle
Contractile Fiber
Perinuclear Region Of Cytoplasm
Presynapse
Molecular Function
GTPase Activity
Structural Molecule Activity
Protein Binding
GTP Binding
Identical Protein Binding
Molecular Adaptor Activity
Protease Binding
Protein Kinase Activity
Calcium Ion Binding
Protein Binding
Kinase Activity
Protein Kinase Binding
Protein Kinase Activator Activity
Ionotropic Glutamate Receptor Binding
Alpha-tubulin Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Ephrin Receptor Binding
Beta-tubulin Binding
Actin Filament Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Synaptic Vesicle Targeting
Regulation Of Exocytosis
Adult Behavior
Cellular Protein Localization
Social Behavior
Cytoskeleton-dependent Cytokinesis
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Microtubule Cytoskeleton Organization
Neuron Migration
Neuron Cell-cell Adhesion
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Axon Guidance
Axonal Fasciculation
Brain Development
Embryo Development Ending In Birth Or Egg Hatching
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebellum Development
Superior Olivary Nucleus Maturation
Hippocampus Development
Layer Formation In Cerebral Cortex
Neuron Differentiation
Negative Regulation Of Axon Extension
Positive Regulation Of Microtubule Polymerization
Neuron Projection Development
Activation Of Protein Kinase Activity
Regulation Of Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Serine Phosphorylation Of STAT Protein
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Rhythmic Process
Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Synaptic Vesicle Cycle
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Drugs
Indirubin-3'-monoxime
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Interacting Genes
23 interacting genes:
APP
CDK5R1
DDIT4L
KAT7
KIDINS220
LSM8
MAGEA2
MAGEA2B
MAPK6
MYOG
PFN2
PLEKHF2
PRKN
SEPTIN1
SEPTIN11
SEPTIN12
SEPTIN2
SEPTIN4
SEPTIN7
SEPTIN8
SPG21
STX1A
STX4
31 interacting genes:
ACTN1
AMPH
APP
BLOC1S6
CAMK2A
CAPN1
CAPN2
CDK16
CDK5
CDK5RAP1
CDK5RAP2
CDK5RAP3
CDK9
CHN1
CTNNB1
HSP90AA1
KRT40
KRTAP10-3
LMTK2
MTUS2
NEDD4
NES
NOTCH2NLA
ODF1
PAK1
SEPTIN5
SET
SIAH1
STXBP1
TSC22D4
TTBK1
Entrez ID
5413
8851
HPRD ID
04100
04586
Ensembl ID
ENSG00000184702
ENSG00000176749
Uniprot IDs
Q99719
X5DNA9
Q15078
Q8N619
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
6LDP
7CNG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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