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PLXNB1 and L1CAM
Data Source:
BioGRID
(two hybrid)
PLXNB1
L1CAM
Description
plexin B1
L1 cell adhesion molecule
Image
No pdb structure
GO Annotations
Cellular Component
Semaphorin Receptor Complex
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Neuronal Cell Body
Axonal Growth Cone
Collagen-containing Extracellular Matrix
Molecular Function
Transmembrane Signaling Receptor Activity
GTPase Activator Activity
Protein Binding
Semaphorin Receptor Activity
Semaphorin Receptor Binding
GTPase Activating Protein Binding
Signaling Receptor Activity
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Biological Process
Negative Regulation Of Cell Adhesion
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Shape
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Migration
Regulation Of Cell Migration
Negative Regulation Of Osteoblast Proliferation
Intracellular Signal Transduction
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Ossification Involved In Bone Maturation
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Semaphorin-plexin Signaling Pathway
Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Inhibitory Synapse Assembly
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Leukocyte Migration
Axon Development
Pathways
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Drugs
Ethanol
Diseases
Hereditary spastic paraplegia (SPG)
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Estimated glomerular filtration rate (
31152163
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
14 interacting genes:
ARHGEF11
ARHGEF12
KMT2A
L1CAM
MET
NRP1
NRP2
PLXNA1
RAC1
RND1
RND3
SEMA4B
SEMA4D
SOX4
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
Entrez ID
5364
3897
HPRD ID
03032
02394
Ensembl ID
ENSG00000164050
ENSG00000198910
Uniprot IDs
O43157
P32004
PDB IDs
2JPH
2OS6
2R2O
2REX
3HM6
3OL2
3SU8
3SUA
5B4W
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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