PLXNA2 and CEMIP

Data Source:
HPRD (two hybrid)

		PLXNA2	CEMIP
Description		plexin A2	cell migration inducing hyaluronidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle Membrane Clathrin-coated Endocytic Vesicle
	Molecular Function	Protein Binding Semaphorin Receptor Activity Identical Protein Binding	Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Clathrin Heavy Chain Binding ER Retention Sequence Binding
	Biological Process	Somitogenesis Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Centrosome Localization Pharyngeal System Development Limb Bud Formation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Sensory Perception Of Sound Positive Regulation Of Peptidyl-threonine Phosphorylation Hyaluronan Biosynthetic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Kinase C Activity
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions	Hyaluronan biosynthesis and export
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Bitter alcoholic beverage consumption ( 31046077) Cardiac hypertrophy ( 21348951) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) General risk tolerance (MTAG) ( 30643258) Lung cancer in never smokers ( 28604730) Manganese levels ( 26025379) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)	Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010)
Interacting Genes		6 interacting genes: CEMIP DHX37 FNBP4 HACE1 IFT80 UBAP2L	1 interacting genes: PLXNA2
Entrez ID		5362	57214
HPRD ID		03033	10519
Ensembl ID		ENSG00000076356	ENSG00000103888
Uniprot IDs		O75051	Q8WUJ3
PDB IDs		3Q3J
Enriched GO Terms of Interacting Partners?
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