PLOD1 and MIR221

Data Source:
BioGRID (unspecified method)

		PLOD1	MIR221
Description		procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	microRNA 221
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Extracellular Exosome Catalytic Complex	Extracellular Space Extracellular Vesicle
	Molecular Function	Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Response To Hypoxia Protein O-linked Glycosylation Epidermis Development Peptidyl-lysine Hydroxylation Protein Phosphopantetheinylation	Negative Regulation Of Cell Population Proliferation Response To Glucose Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Interleukin-21 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Regeneration Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Necroptotic Process Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Schwann Cell Migration Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Negative Regulation Of Double-strand Break Repair
Pathways		Collagen biosynthesis and modifying enzymes
Drugs		Ascorbic acid
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Nevo syndrome
GWAS		Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Moyamoya disease ( 29273593) Platelet count ( 27863252) Plateletcrit ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		40 interacting genes: MIR1-2 MIR10B MIR122 MIR128-2 MIR141 MIR143 MIR15A MIR15B MIR17 MIR18A MIR18B MIR199A2 MIR19A MIR19B1 MIR206 MIR20A MIR214 MIR221 MIR222 MIR29B1 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I USP4	87 interacting genes: ADARB1 AIMP2 APOBEC3B AQR C1QBP CELF1 CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		5351	407006
HPRD ID		01086
Ensembl ID		ENSG00000083444	ENSG00000207870
Uniprot IDs		Q02809
PDB IDs
Enriched GO Terms of Interacting Partners?
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