PLD2 and PIP5K1A

Data Source:
HPRD (in vivo, in vitro)

		PLD2	PIP5K1A
Description		phospholipase D2	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility	Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis	Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Choline Choline salicylate
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Body mass index ( 26426971)
Interacting Genes		29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL	16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC
Entrez ID		5338	8394
HPRD ID		03857	04470
Ensembl ID		ENSG00000129219	ENSG00000143398
Uniprot IDs		O14939	A6PW57 Q99755
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS
Enriched GO Terms of Interacting Partners?
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