BTBD1 and TRIM5

Data Source:
HPRD (in vitro)

		BTBD1	TRIM5
Description		BTB domain containing 1	tripartite motif containing 5
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytosol Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule	P-body Nucleoplasm Cytoplasm Cytosol Omegasome
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Muscle Organ Development Protein Ubiquitination Neurogenesis Regulation Of Protein Binding Post-translational Protein Modification	Protein Polyubiquitination Activation Of Innate Immune Response Autophagy Regulation Of Gene Expression Positive Regulation Of Autophagy Viral Process Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 31152163) Kawasaki disease ( 21326860)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010 32888494) Serum alkaline phosphatase levels ( 29403010) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)
Interacting Genes		10 interacting genes: CUL3 LNX1 MPP3 MTNR1B NTAQ1 PSMD5 RNF4 TOP1 TRIM5 TULP3	46 interacting genes: BTBD1 BTBD2 EHHADH EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1
Entrez ID		53339	85363
HPRD ID		12251	07004
Ensembl ID		ENSG00000064726	ENSG00000132256
Uniprot IDs		A0A024R224 Q9H0C5	Q9C035
PDB IDs			2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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