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PKM and HIF1A
Data Source:
BioGRID
(affinity chromatography technology, pull down)
PKM
HIF1A
Description
pyruvate kinase M1/2
hypoxia inducible factor 1 subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Rough Endoplasmic Reticulum
Cytosol
Cilium
Vesicle
Secretory Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Pyruvate Kinase Complex
Extracellular Vesicle
Ficolin-1-rich Granule Lumen
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Body
Nuclear Speck
Motile Cilium
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Axon Cytoplasm
Molecular Function
Magnesium Ion Binding
RNA Binding
MRNA Binding
Pyruvate Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
MHC Class II Protein Complex Binding
Potassium Ion Binding
Identical Protein Binding
ADP Binding
Cadherin Binding
Thyroid Hormone Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Histone Acetyltransferase Binding
Nuclear Hormone Receptor Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
E-box Binding
Biological Process
Response To Hypoxia
Liver Development
Glycolytic Process
ATP Biosynthetic Process
Response To Nutrient
Response To Gravity
Programmed Cell Death
Response To Muscle Inactivity
Animal Organ Regeneration
Cellular Response To Insulin Stimulus
Pyruvate Biosynthetic Process
Neutrophil Degranulation
Skeletal Muscle Tissue Regeneration
Canonical Glycolysis
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Cytoplasmic Translation
Response To Reactive Oxygen Species
Angiogenesis
Response To Hypoxia
Neural Crest Cell Migration
Epithelial To Mesenchymal Transition
Embryonic Placenta Development
B-1 B Cell Homeostasis
Positive Regulation Of Endothelial Cell Proliferation
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Cytokine Production Involved In Inflammatory Response
Outflow Tract Morphogenesis
Cardiac Ventricle Morphogenesis
Lactate Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cellular Iron Ion Homeostasis
Signal Transduction
Lactation
Visual Learning
Response To Iron Ion
Regulation Of Gene Expression
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Response To Muscle Activity
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Cytokine-mediated Signaling Pathway
Axonal Transport Of Mitochondrion
Neural Fold Elevation Formation
Cerebral Cortex Development
Negative Regulation Of Bone Mineralization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of TOR Signaling
Oxygen Homeostasis
Positive Regulation Of Chemokine Production
Regulation Of Transforming Growth Factor Beta2 Production
Collagen Metabolic Process
Embryonic Hemopoiesis
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Hemoglobin Biosynthetic Process
Glucose Homeostasis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Post-translational Protein Modification
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Growth
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Hormone Biosynthetic Process
Digestive Tract Morphogenesis
Positive Regulation Of Nitric-oxide Synthase Activity
Cartilage Development
Elastin Metabolic Process
Intestinal Epithelial Cell Maturation
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Iris Morphogenesis
Retina Vasculature Development In Camera-type Eye
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of Thymocyte Apoptotic Process
Cellular Response To Interleukin-1
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Hypoxia-inducible Factor-1alpha Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Autophagy Of Mitochondrion
Regulation Of Aerobic Respiration
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Protein Neddylation
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
Neutrophil degranulation
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
NOTCH1 Intracellular Domain Regulates Transcription
Circadian Clock
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
PTK6 Expression
PTK6 promotes HIF1A stabilization
Neddylation
Drugs
Pyruvic acid
L-Phospholactate
2-Phosphoglycolic Acid
6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
Copper
Artenimol
Carvedilol
Hydralazine
2-Methoxyestradiol
ENMD-1198
PX-478
FG-2216
Diseases
GWAS
Interacting Genes
55 interacting genes:
ANXA7
APP
ARAF
AURKB
CCR4
CDC25A
CDK4
CDKN1A
CTNNB1
DLC1
DUX4
EGLN3
ENO3
EPM2A
EXOSC5
FGFR1
GRB7
HERC1
HIF1A
HULC
KPNA1
LINC01554
LMO7
LNX1
MAPK1
MDM2
MYL2
MYOC
NAGK
NDRG1
NXT2
OLFM2
PAX8
PIN1
POLE2
PRKN
PTEN
RAF1
RAP1B
RCC1
RELA
RPP14
SHBG
SMN1
SORBS2
SUMO1
SUMO2
TERF1
TINF2
TK1
TRIM35
TRIM55
TRIM63
UCHL5
YWHAQ
125 interacting genes:
AKT1
APEX1
AR
ARNT
ARNT2
ARNTL
ATM
AURKA
BNIP3
CASR
CCND2
CDC34
CDK4
CDK6
CDKN2A
CDKN2B
CITED2
COPS5
CREB3L1
CREBBP
CSNK1D
CSNK2A1
CTNNB1
DAP3
E2F7
EAF2
EGLN1
EGLN2
EGLN3
EIF5A2
EP300
EPHA2
EPO
ESRRA
ESRRB
ESRRG
ETV4
F12
FGFR4
FZR1
GATA3
GLIS2
HDAC1
HDAC2
HDAC3
HDAC5
HIF1A-AS2
HIF1AN
HIF3A
HNF4A
HSP90AA1
IKBKG
ISG15
JUN
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LATS2
LINC01139
LRRK2
MAFG
MAFK
MAP2K3
MAP2K5
MAPK1
MAPK3
MAX
MCL1
MCM7
MDM2
MTA1
MYC
NAA10
NAA11
NBN
NCOA1
NCOA2
NDN
NEDD8
NF2
NQO1
NR4A1
OS9
PER1
PGK1
PKM
PLD1
PLD2
PLK3
PRKACA
PSMA7
PTBP1
PTK6
RACGAP1
RACK1
RB1
RORA
RUNX2
RWDD3
SAT1
SEPTIN9
SIRT2
SMAD3
SP1
SSX4
STAT3
STK11
STUB1
SUCO
SUMO1
TEAD2
TP53
TSGA10
UBE2D1
UBE2I
USP19
USP20
USP28
USP7
VEGFA
VHL
VHLL
ZC3H12A
Entrez ID
5315
3091
HPRD ID
01529
04517
Ensembl ID
ENSG00000067225
ENSG00000100644
Uniprot IDs
A0A024R5Z9
B4DNK4
P14618
V9HWB8
D0VY79
Q16665
PDB IDs
1T5A
1ZJH
3BJF
3BJT
3G2G
3GQY
3GR4
3H6O
3ME3
3SRD
3SRF
3SRH
3U2Z
4B2D
4FXF
4FXJ
4G1N
4JPG
4QG6
4QG8
4QG9
4QGC
4RPP
4WJ8
4YJ5
5X0I
5X1V
5X1W
6B6U
6GG3
6GG4
6GG5
6GG6
6JFB
6NU1
6NU5
6NUB
6TTF
6TTH
6TTI
6TTQ
6V74
6V75
6V76
6WP3
6WP4
6WP5
6WP6
1D7G
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
2ILM
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
Enriched GO Terms of Interacting Partners
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