PIM1 and NUMA1

Data Source:
HPRD (in vitro, in vivo)

		PIM1	NUMA1
Description		Pim-1 proto-oncogene, serine/threonine kinase	nuclear mitotic apparatus protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Centrosome Spindle Cytosol Spindle Microtubule Cell Cortex Lateral Plasma Membrane Nuclear Matrix Extrinsic Component Of Plasma Membrane Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Manganese Ion Binding Ribosomal Small Subunit Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Structural Molecule Activity Protein Binding Microtubule Binding Protein C-terminus Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Multicellular Organism Development Cytokine-mediated Signaling Pathway Regulation Of Transmembrane Transporter Activity Hyaluronan Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Positive Regulation Of Cardiac Muscle Cell Proliferation Vitamin D Receptor Signaling Pathway Positive Regulation Of Brown Fat Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Cardioblast Proliferation Cellular Detoxification	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly
Pathways		Interleukin-4 and Interleukin-13 signaling STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
Drugs		3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Staurosporine LY-294002 Imidazole (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Bisindolylmaleimide I Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine IMIDAZOPYRIDAZIN 1 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Tricetin 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine 2,3-diphenyl-1H-indole-7-carboxylic acid Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Rosacea symptom severity ( 29771307)	Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		34 interacting genes: ABCB1 APP BAD BANP BEND7 CBX1 CBX3 CDC20 CDC25A CDKN1A DAPK1 EGFR EPHA3 FBXO7 FH FXR2 H3-3A H3-4 H3C14 HEXIM2 HSP90AA1 NFATC1 NHLH1 NUMA1 PPP2CA PTPRO SENP1 SHMT1 SKP2 SND1 SNX6 TFPT UBE2I ZBTB1	25 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A SUMO2 TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ
Entrez ID		5292	4926
HPRD ID		01292	01236
Ensembl ID		ENSG00000137193	ENSG00000137497
Uniprot IDs		A0A024RD25 P11309	A0A024R5M9 Q14980 Q3SYK8 Q4LE64
PDB IDs		1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2O3P 2O63 2O64 2O65 2OBJ 2OI4 2XIX 2XIY 2XIZ 2XJ0 2XJ1 2XJ2 3A99 3BGP 3BGQ 3BGZ 3BWF 3C4E 3CXW 3CY2 3CY3 3DCV 3F2A 3JPV 3JXW 3JY0 3JYA 3MA3 3QF9 3R00 3R01 3R02 3R04 3T9I 3UIX 3UMW 3UMX 3VBQ 3VBT 3VBV 3VBW 3VBX 3VBY 3VC4 3WE8 4A7C 4ALU 4ALV 4ALW 4AS0 4BZN 4BZO 4DTK 4ENX 4ENY 4GW8 4I41 4IAA 4JX3 4JX7 4K0Y 4K18 4K1B 4LL5 4LM5 4LMU 4MBI 4MBL 4MED 4MTA 4N6Y 4N6Z 4N70 4RBL 4RC2 4RC3 4RC4 4RPV 4TY1 4WRS 4WSY 4WT6 4XH6 4XHK 5C1Q 5DGZ 5DHJ 5DIA 5DWR 5EOL 5IIS 5IPJ 5KCX 5KGD 5KGE 5KGG 5KGI 5KGK 5KZI 5MZL 5N4N 5N4O 5N4R 5N4U 5N4V 5N4X 5N4Y 5N4Z 5N50 5N51 5N52 5N5L 5N5M 5NDT 5O11 5O12 5O13 5TEL 5TEX 5TOE 5TUR 5V80 5V82 5VUA 5VUB 5VUC 6AYD 6BSK 6KZI 6L11 6L12 6L13 6L14 6L15 6L16 6L17 6MT0 6NO8 6NO9 6PCW 6PDI 6PDN 6PDO 6PDP 6QXK 6VRU 6VRV 6YKD	3RO2 5GXW 6HC2 6QJA
Enriched GO Terms of Interacting Partners?
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