ATP6V0C and PI16

Data Source:
BioGRID (two hybrid)

		ATP6V0C	PI16
Description		ATPase H+ transporting V0 subunit c	peptidase inhibitor 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Space
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Peptidase Inhibitor Activity
	Biological Process	Insulin Receptor Signaling Pathway ATP Synthesis Coupled Proton Transport Viral Process Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Transferrin Transport Ion Transmembrane Transport Neutrophil Degranulation Phagosome Acidification Proton Transmembrane Transport	Negative Regulation Of Peptidase Activity Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases
GWAS			Acne (severe) ( 24927181) Atrial fibrillation ( 30061737) Chemerin levels ( 20237162) Diverticular disease ( 30177863)
Interacting Genes		53 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12	6 interacting genes: ATP6V0C PLP1 STRIT1 TMBIM6 TMEM60 TMEM86A
Entrez ID		527	221476
HPRD ID		00162	11430
Ensembl ID		ENSG00000185883	ENSG00000164530
Uniprot IDs		P27449	Q6UXB8
PDB IDs
Enriched GO Terms of Interacting Partners?
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