PGGT1B and RHOB

Data Source:
HPRD (in vitro)

		PGGT1B	RHOB
Description		protein geranylgeranyltransferase type I subunit beta	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Protein Binding Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Protein Phosphopantetheinylation Protein Prenylation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways			GPVI-mediated activation cascade Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs		L-778123 Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE	Botulinum toxin type A
Diseases
GWAS		Longevity ( 30294719)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		6 interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2	12 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 TNFAIP1
Entrez ID		5229	388
HPRD ID		03612	01321
Ensembl ID		ENSG00000164219	ENSG00000143878
Uniprot IDs		P53609	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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