PF4V1 and CCL21

Data Source:
BioGRID (pull down, pull down)

		PF4V1	CCL21
Description		platelet factor 4 variant 1	C-C motif chemokine ligand 21
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GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding	Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Inflammatory Response Platelet Activation Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Response To Prostaglandin E Mesangial Cell-matrix Adhesion Chemokine (C-C Motif) Ligand 21 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Activation Of GTPase Activity Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Chemokine Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Inflammatory bowel disease ( 23128233)	Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Rheumatoid arthritis ( 30423114 18794853 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		15 interacting genes: CCL11 CCL19 CCL21 CCL22 CCL25 CCL26 CCL27 CCL28 CCL4L1 CXCL10 CXCL11 CXCL12 CXCL13 XCL1 XCL2	32 interacting genes: ACKR2 ACKR4 C3orf52 CCL13 CCL17 CCL23 CCL24 CCL26 CCL28 CCL5 CCR7 CTSD CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 GOT2 IGFBP7 LRRK1 OTP PF4 PF4V1 PPBP TMEM107 UBQLN4 VCAN XCL1 XCL2
Entrez ID		5197	6366
HPRD ID		01427	04113
Ensembl ID		ENSG00000109272	ENSG00000137077
Uniprot IDs		P10720	O00585
PDB IDs		4HSV	2L4N 5EKI
Enriched GO Terms of Interacting Partners?
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