CYB5R1 and CYCS

Data Source:
HPRD (in vitro)

		CYB5R1	CYCS
Description		cytochrome b5 reductase 1	cytochrome c, somatic
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respirasome
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding FAD Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Platelet Degranulation Bicarbonate Transport Sterol Biosynthetic Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration
Pathways		Platelet degranulation Erythrocytes take up carbon dioxide and release oxygen	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		Flavin adenine dinucleotide	Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases			Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		8 interacting genes: CYCS HIGD1C SGTA SGTB SLC51B TTC1 UBQLN1 UBQLN4	22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		51706	54205
HPRD ID		06434	00479
Ensembl ID		ENSG00000159348	ENSG00000172115
Uniprot IDs		Q9UHQ9	G4XXL9 P99999
PDB IDs			1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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