LSM7 and RAB29

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM7	RAB29
Description		LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated	RAB29, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Cytoplasm Mitochondrion Early Endosome Vacuole Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Endomembrane System Symbiont-containing Vacuole Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Intracellular Vesicle
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Kinesin Binding Small GTPase Binding Dynein Complex Binding
	Biological Process	MRNA Splicing, Via Spliceosome Exonucleolytic Catabolism Of Deadenylated MRNA	Positive Regulation Of Receptor Recycling Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitochondrion Organization Golgi Organization Synapse Assembly Response To Bacterium Negative Regulation Of Neuron Projection Development Cell Differentiation Melanosome Organization Viral RNA Genome Replication T Cell Activation Retrograde Transport, Endosome To Golgi Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Intracellular Protein Transport Regulation Of Neuron Death Toxin Transport Protein Localization To Ciliary Membrane Regulation Of Retrograde Transport, Endosome To Golgi
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	RAB geranylgeranylation
Drugs
Diseases
GWAS		Parkinson's disease ( 28892059)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		25 interacting genes: DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SART3 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26	8 interacting genes: BEND7 C11orf49 LDOC1 LRRK1 LSM7 REL TRIM27 TRIM32
Entrez ID		51690	8934
HPRD ID		06287	11962
Ensembl ID		ENSG00000130332	ENSG00000117280
Uniprot IDs		Q9UK45	B2R7I9 O14966 Q6FGU7
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	6HH2
Enriched GO Terms of Interacting Partners?
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