ASB2 and FLNB

Data Source:
BioGRID (enzymatic study)

		ASB2	FLNB
Description		ankyrin repeat and SOCS box containing 2	filamin B
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Skeletal Muscle Cell Differentiation Post-translational Protein Modification	Signal Transduction Muscle Organ Development Actin Cytoskeleton Organization Cell Differentiation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism
Drugs
Diseases			Spondylocarpotarsal synostosis syndrome FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome
GWAS		Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Sum eosinophil basophil counts ( 27863252)	Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31217584) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171 28073927) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: ELOB FLNA FLNB SMAD9 UBC UBE2D1	22 interacting genes: ASB2 ATF7IP ERBB2 FBLIM1 FLNA GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR
Entrez ID		51676	2317
HPRD ID		05768	04543
Ensembl ID		ENSG00000100628	ENSG00000136068
Uniprot IDs		A0A024R6E7 Q96Q27	O75369
PDB IDs			2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP
Enriched GO Terms of Interacting Partners?
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