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PDK1 and ITGB3
Data Source:
BioGRID
(enzymatic study)
PDK1
ITGB3
Description
pyruvate dehydrogenase kinase 1
integrin subunit beta 3
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Mitochondrial Pyruvate Dehydrogenase Complex
Nucleus
Nucleoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
Cell Surface
Platelet Alpha Granule Membrane
Lamellipodium Membrane
Filopodium Membrane
Microvillus Membrane
Ruffle Membrane
Protein-containing Complex
Integrin Alphav-beta3 Complex
Alphav-beta3 Integrin-PKCalpha Complex
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Alphav-beta3 Integrin-HMGB1 Complex
Melanosome
Receptor Complex
Synapse
Postsynaptic Membrane
Extracellular Exosome
Alphav-beta3 Integrin-vitronectin Complex
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity
Protein Binding
ATP Binding
Virus Receptor Activity
Fibronectin Binding
Protease Binding
Protein Disulfide Isomerase Activity
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Coreceptor Activity
Fibroblast Growth Factor Binding
Enzyme Binding
C-X3-C Chemokine Binding
Insulin-like Growth Factor I Binding
Neuregulin Binding
Identical Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Cell Adhesion Molecule Binding
Extracellular Matrix Binding
Fibrinogen Binding
Biological Process
Glucose Metabolic Process
Protein Phosphorylation
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate
Regulation Of Glucose Metabolic Process
Hypoxia-inducible Factor-1alpha Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Platelet Degranulation
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Blood Coagulation
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Smooth Muscle Cell Migration
Cell Migration
Protein Phosphopantetheinylation
Platelet Activation
Extracellular Matrix Organization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Activation Of Protein Kinase Activity
Negative Regulation Of Lipid Transport
Regulation Of Protein Localization
Cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Tube Development
Apolipoprotein A-I-mediated Signaling Pathway
Wound Healing
Apoptotic Cell Clearance
Regulation Of Bone Resorption
Viral Entry Into Host Cell
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Mesodermal Cell Differentiation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Lipoprotein Metabolic Process
Leukocyte Migration
Negative Chemotaxis
Regulation Of Serotonin Uptake
Angiogenesis Involved In Wound Healing
Platelet Aggregation
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Pathways
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid
Platelet degranulation
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Syndecan interactions
Syndecan interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
Signal transduction by L1
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE
Dichloroacetic acid
Abciximab
Eptifibatide
Antithymocyte immunoglobulin (rabbit)
Levothyroxine
Tirofiban
Resveratrol
Lefradafiban
LM-609
Fradafiban
Ferric maltol
Diseases
Glanzmann thrombasthenia
Allograft rejection
GWAS
Blood protein levels (
28240269
)
Erectile dysfunction in type 1 diabetes (
22704111
)
Fasting plasma glucose (
25187374
)
Body mass index (
25673413
)
Brain morphology (MOSTest) (
32665545
)
Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure (
31586183
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
High chromosomal aberration frequency (chromosome type) (
31586183
)
Mean platelet volume (
27863252
)
Medication use (thyroid preparations) (
31015401
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Interacting Genes
14 interacting genes:
AKT1
DLAT
FGFR1
ITGB3
KAT2B
LAMTOR5
PDHA1
PDK2
PIK3CA
RPS6KB1
SGK1
USP4
XRCC6
YWHAQ
49 interacting genes:
AKT1
ANGPTL3
APP
CAPN1
CD36
CDK1
COL1A2
DAB1
DAB2
DOK1
EPS8
FBLN2
FGA
FGFR1
FGG
FLNA
FLNB
FN1
GRIA2
HRAS
ILK
ITGA2B
ITGA5
ITGAV
ITGB3BP
KDR
MAPK3
NID1
NUMB
P2RY2
P4HB
PDGFRA
PDGFRB
PDK1
PDPK1
PECAM1
PLA2G2A
PLA2G4A
PTK2
PTK2B
PXN
SHC1
SRC
TGM2
THBS1
THY1
TLN1
TNS2
VTN
Entrez ID
5163
3690
HPRD ID
03954
01428
Ensembl ID
ENSG00000152256
ENSG00000259207
Uniprot IDs
B7Z7N6
Q15118
P05106
PDB IDs
2Q8F
2Q8G
2Q8H
1JV2
1KUP
1KUZ
1L5G
1M1X
1M8O
1MIZ
1MK7
1MK9
1RN0
1S4X
1TYE
1U8C
2INI
2K9J
2KNC
2KV9
2L1C
2L91
2LJD
2LJE
2LJF
2MTP
2N9Y
2Q6W
2RMZ
2RN0
2VC2
2VDK
2VDL
2VDM
2VDN
2VDO
2VDP
2VDQ
2VDR
3FCS
3FCU
3IJE
3NID
3NIF
3NIG
3T3M
3T3P
3ZDX
3ZDY
3ZDZ
3ZE0
3ZE1
3ZE2
4CAK
4G1E
4G1M
4MMX
4MMY
4MMZ
4O02
4Z7N
4Z7O
4Z7Q
5HDB
6AVQ
6AVR
6AVU
6BXB
6BXF
6BXJ
6CKB
6MK0
6MSL
6MSU
6NAJ
6V4P
Enriched GO Terms of Interacting Partners
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