PEX5L and HCN1

Data Source:
BioGRID (pull down)

		PEX5L	HCN1
Description		peroxisomal biogenesis factor 5 like	hyperpolarization activated cyclic nucleotide gated potassium channel 1
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisomal Membrane Cytosol Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite HCN Channel Complex
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Small GTPase Binding	Intracellular CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Voltage-gated Cation Channel Activity CAMP Binding Identical Protein Binding
	Biological Process	Protein Import Into Peroxisome Matrix, Docking Regulation Of CAMP-mediated Signaling	Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Apical Protein Localization Retinal Cone Cell Development Protein Homotetramerization Cellular Response To CAMP Potassium Ion Transmembrane Transport
Pathways			HCN channels
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood metabolite levels ( 24816252) Childhood body mass index ( 33045005) Glucose homeostasis traits ( 25524916) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 21490949)	Adventurousness ( 30643258) Age at first birth ( 27798627) Age at first sexual intercourse ( 27089180) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Electrocardiographic traits ( 32602732) Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Irritable mood ( 29500382) Non-response to bupropion and depression ( 27622933) Number of sexual partners ( 30643258) P wave duration ( 28794112) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Spatial memory ( 31596458) Squamous cell lung carcinoma ( 28604730) Survival in colon cancer ( 25866641) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)
Interacting Genes		3 interacting genes: HCN1 PEX7 RAF1	2 interacting genes: HCN2 PEX5L
Entrez ID		51555	348980
HPRD ID		11425	09099
Ensembl ID		ENSG00000114757	ENSG00000164588
Uniprot IDs		Q8IYB4	O60741 Q86WJ6
PDB IDs			5U6O 5U6P 6UQF 6UQG
Enriched GO Terms of Interacting Partners?
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