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DTL and DDB1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
DTL
DDB1
Description
denticleless E3 ubiquitin protein ligase homolog
damage specific DNA binding protein 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Centrosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Nuclear Membrane
Cul4-RING E3 Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Protein-containing Complex
Site Of Double-strand Break
Extracellular Exosome
Cul4-RING E3 Ubiquitin Ligase Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Protein-containing Complex Binding
WD40-repeat Domain Binding
Cullin Family Protein Binding
Biological Process
Protein Polyubiquitination
DNA Replication
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Response To UV
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Post-translational Protein Modification
Positive Regulation Of Protein Catabolic Process
Rhythmic Process
Regulation Of Cell Cycle
Signal Transduction Involved In G2 DNA Damage Checkpoint
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Proteasomal Protein Catabolic Process
Viral Process
Protein Ubiquitination
Nucleotide-excision Repair, DNA Incision
Histone H2A Monoubiquitination
DNA Damage Response, Detection Of DNA Damage
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Viral Genome Replication
Positive Regulation Of Gluconeogenesis
Positive Regulation Of Protein Catabolic Process
Positive Regulation By Virus Of Viral Protein Levels In Host Cell
Rhythmic Process
Biological Process Involved In Interaction With Symbiont
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Viral Release From Host Cell
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Neddylation
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Appendicular lean mass (
33097823
)
Birth weight (
31043758
27680694
)
Height (
20881960
)
Large artery stroke (
28265093
)
Nickel levels (
26025379
)
Plateletcrit (
32888494
)
Interacting Genes
17 interacting genes:
ATR
CDK1
CDK2
CDKN1A
CDT1
CHEK1
DDB1
KAT2A
KMT5A
PCNA
POLD4
RBX1
TDG
TOB1
TP53
UBE2D1
UBE2N
44 interacting genes:
ABL1
BRAP
CNOT2
COPS2
COPS5
COPS8
CUL4A
CUL4B
DCAF11
DCAF8
DDB2
DET1
DNMT3A
DNMT3B
DTL
EME1
ERCC8
GPS1
GSPT1
H1-2
H3C1
HOXD3
IKZF1
IP6K1
LMO4
MEF2A
MUS81
PIN1
PTEN
RASSF1
SALL2
SIN3A
SIRT7
SKP2
STAT1
SUPT3H
SUV39H1
TP73
USP40
VAMP3
WDTC1
WIPI2
XPA
ZNF277
Entrez ID
51514
1642
HPRD ID
17952
10952
Ensembl ID
ENSG00000143476
ENSG00000167986
Uniprot IDs
B4E0E6
Q9NZJ0
Q16531
PDB IDs
6QC0
2B5L
2B5M
2B5N
2HYE
3E0C
3EI1
3EI2
3EI3
3EI4
3I7H
3I7K
3I7L
3I7N
3I7O
3I7P
3I89
3I8C
3I8E
4A08
4A09
4A0A
4A0B
4A0K
4A0L
4A11
4CI1
4CI2
4CI3
4E54
4E5Z
4TZ4
5FQD
5HXB
5JK7
5V3O
6BN7
6BN8
6BN9
6BNB
6BOY
6DSZ
6FCV
6H0F
6H0G
6PAI
6Q0R
6Q0V
6Q0W
6R8Y
6R8Z
6R90
6R91
6R92
6SJ7
6TD3
6UD7
6UE5
6UML
Enriched GO Terms of Interacting Partners
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