ANGPT4 and TIE1

Data Source:
BioGRID (pull down)

		ANGPT4	TIE1
Description		angiopoietin 4	tyrosine kinase with immunoglobulin like and EGF like domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Notch Signaling Pathway Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cellular Response To Hypoxia	Angiogenesis Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Positive Regulation Of Kinase Activity Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly
Pathways		Tie2 Signaling
Drugs			Fostamatinib
Diseases
GWAS		Food allergy ( 29030101) Intracranial aneurysm ( 29531279) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Peanut allergy ( 29030101)	Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: RHOU TEK TIE1	13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1
Entrez ID		51378	7075
HPRD ID		04747	02572
Ensembl ID		ENSG00000101280	ENSG00000066056
Uniprot IDs		Q9Y264	B4DTW8 P35590
PDB IDs			5N06
Enriched GO Terms of Interacting Partners?
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