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POMP and PSMB8
Data Source:
BioGRID
(two hybrid)
POMP
PSMB8
Description
proteasome maturation protein
proteasome 20S subunit beta 8
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Nuclear Speck
Organelle Membrane
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Extracellular Exosome
Spermatoproteasome Complex
Molecular Function
Protein Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Proteasome Assembly
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
Fat Cell Differentiation
T Cell Receptor Signaling Pathway
Regulation Of Endopeptidase Activity
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Type I Interferon Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Interferon alpha/beta signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Carfilzomib
Diseases
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome
GWAS
Breast cancer (menopausal hormone therapy interaction) (
24080446
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Asthma (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
IgA nephropathy (
25305756
)
Nephropathy (
21399633
)
Interacting Genes
25 interacting genes:
ARMT1
ATXN1
CAPN3
ECT2
FAM107A
GPD1
GRB2
KCNA10
KIF1B
KLHL41
MPPED2
PSMA1
PSMA3
PSMB1
PSMB10
PSMB5
PSMB6
PSMB7
PSMB8
PSMB9
PYGM
RBM5
SSR4
TTN
VCL
24 interacting genes:
ABCB1
DUSP23
GNPNAT1
INCA1
LSM1
MEOX2
NFKBID
PFDN5
POLR2G
POMP
PSMA6
PSMB10
PSMB9
REL
SNX5
TAP1
TAP2
TENT5B
TRAF3
TRIP13
UBAP2
WWOX
YJEFN3
ZMYND12
Entrez ID
51371
5696
HPRD ID
12613
01515
Ensembl ID
ENSG00000132963
ENSG00000204264
Uniprot IDs
Q9Y244
P28062
X5CMJ9
PDB IDs
5L5A
5L5B
5L5D
5L5E
5L5F
5L5H
5L5I
5L5J
5L5O
5L5P
5L5Q
5L5R
5L5S
5L5T
5L5U
5L5V
5LTT
5M2B
6AVO
6E5B
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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