RXFP3 and HSP90B1

Data Source:
BioGRID (two hybrid)

		RXFP3	HSP90B1
Description		relaxin family peptide receptor 3	heat shock protein 90 beta family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Positive Regulation Of Cytokinesis	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		G alpha (i) signalling events Relaxin receptors	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS			Blood protein levels ( 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		10 interacting genes: APP ENO1 GNAS HSP90B1 KATNB1 NCKIPSD RLN3 TMEM248 TTC19 YWHAE	36 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CCT2 CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTEN PTPN11 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		51289	7184
HPRD ID		17979	01860
Ensembl ID		ENSG00000182631	ENSG00000166598
Uniprot IDs		Q9NSD7	P14625 V9HWP2
PDB IDs			4NH9
Enriched GO Terms of Interacting Partners?
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