PCOLCE and ECT2

Data Source:
BioGRID (two hybrid)

		PCOLCE	ECT2
Description		procollagen C-endopeptidase enhancer	epithelial cell transforming 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Multicellular Organism Development Positive Regulation Of Peptidase Activity	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Collagen biosynthesis and modifying enzymes Crosslinking of collagen fibrils	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Resting heart rate ( 27798624) Subcortical volume (MOSTest) ( 32665545)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		5 interacting genes: COL2A1 COL3A1 ECT2 HMGB1 PLG	38 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2
Entrez ID		5118	1894
HPRD ID		02603	11860
Ensembl ID		ENSG00000106333	ENSG00000114346
Uniprot IDs		Q15113	Q9H8V3
PDB IDs		1UAP 6FZV 6FZW	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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