INSIG2 and MMGT1

Data Source:
BioGRID (two hybrid)

		INSIG2	MMGT1
Description		insulin induced gene 2	membrane magnesium transporter 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Golgi Membrane Early Endosome Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Early Endosome Membrane EMC Complex
	Molecular Function	Protein Binding Oxysterol Binding	Protein Binding Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity Membrane Insertase Activity
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum	Cobalt Ion Transport Copper Ion Transport Magnesium Ion Transport Iron Ion Transmembrane Transport Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane Magnesium Ion Transmembrane Transport
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Miscellaneous transport and binding events
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)
Interacting Genes		46 interacting genes: ABHD4 AQP2 AQP6 ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP FAM209A GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MUC1 NEMP1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC16A10 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21	51 interacting genes: ADGRE2 AGR3 ANKRD46 APP C4orf3 C5 C8A DEFB127 EMD FIS1 FXYD6 GPR25 GRM2 INSIG2 ITGAM LNPEP MFF MFSD3 MFSD5 MS4A13 NDUFA3 NINJ2 ORMDL2 PEX16 PLPP6 RUSF1 SEC22B SLC35B4 SLC35E4 SLC38A7 SLC7A14 STX12 STX1A STX1B STX3 STX6 STX8 TAS2R19 TECR THBD TMBIM6 TMED8 TMEM14A TMEM14C TMEM229B TMEM254 TMEM42 TMEM60 TMEM86B VRK2 YIF1A
Entrez ID		51141	93380
HPRD ID		16361	06626
Ensembl ID		ENSG00000125629	ENSG00000169446
Uniprot IDs		A0A024RAI2 B4DQ23 Q9Y5U4	Q8N4V1
PDB IDs		4J82	6WW7 6Z3W
Enriched GO Terms of Interacting Partners?
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