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APH1A and FIS1
Data Source:
BioGRID
(two hybrid)
APH1A
FIS1
Description
aph-1 homolog A, gamma-secretase subunit
fission, mitochondrial 1
Image
GO Annotations
Cellular Component
Mitochondrion
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Endosome Membrane
Membrane
Integral Component Of Membrane
Golgi Cisterna Membrane
Gamma-secretase Complex
Integral Component Of Presynaptic Membrane
Mitochondrion
Peroxisome
Integral Component Of Peroxisomal Membrane
Endoplasmic Reticulum
Membrane
Integral Component Of Mitochondrial Outer Membrane
Protein-containing Complex
Molecular Function
Protein Binding
Enzyme Binding
Protein-macromolecule Adaptor Activity
Endopeptidase Activator Activity
Protein Binding
Identical Protein Binding
Biological Process
Metanephros Development
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Positive Regulation Of Endopeptidase Activity
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Cellular Protein Metabolic Process
Ephrin Receptor Signaling Pathway
Mitochondrial Fission
Autophagy Of Mitochondrion
Release Of Cytochrome C From Mitochondria
Protein Targeting To Mitochondrion
Positive Regulation Of Cytosolic Calcium Ion Concentration
Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Peroxisome Fission
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Calcium-mediated Signaling Using Intracellular Calcium Source
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Mitochondrion Morphogenesis
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Protein Targeting To Membrane
Negative Regulation Of ATP Metabolic Process
Negative Regulation Of Fatty Acid Transport
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Amyloid fiber formation
Class I peroxisomal membrane protein import
Drugs
E-2012
Diseases
GWAS
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
26955885
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Morning vs. evening chronotype (
26955885
26835600
)
Refractive error (
32231278
)
Schizophrenia (
25056061
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Rheumatoid arthritis (
30891314
)
Interacting Genes
36 interacting genes:
ANKRD46
APOD
ASGR1
ATF4
BHLHE40
CREB3
DRD2
FIS1
FXYD6
GLP1R
GPATCH8
GPR35
HES1
HIVEP1
IGFBP5
KLF11
LAT
MFSD6
MPP1
MRAP2
NCSTN
PSEN1
PSEN2
PSENEN
RBFOX2
SCAND1
SERP1
SLC38A7
SLC39A9
SMAGP
THPO
TLE1
TMED10
TMEM140
TMEM218
TRARG1
30 interacting genes:
A2M
ABHD6
APH1A
BCAP31
CREB3
DNM1L
EBP
ERGIC3
FAM209A
FAM210B
FFAR2
JAGN1
KASH5
KCNJ6
MARCHF5
MMGT1
NOS3
PIGP
RNASEK
SCN3B
SLC10A6
SLC14A1
SLC22A1
SLC22A2
SPCS1
TBC1D15
TMEM14B
TMPPE
UBC
VKORC1
Entrez ID
51107
51024
HPRD ID
06360
12352
Ensembl ID
ENSG00000117362
ENSG00000214253
Uniprot IDs
B4DUG7
Q96BI3
Q9Y3D6
PDB IDs
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
1NZN
1PC2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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