PAX6 and LHX2

Data Source:
BioGRID (pull down)

		PAX6	LHX2
Description		paired box 6	LIM homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Histone Acetyltransferase Binding R-SMAD Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Eye Development Pancreatic A Cell Development Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Visual Perception Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Gene Expression Ventral Spinal Cord Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Anatomical Structure Development Negative Regulation Of Neurogenesis Iris Morphogenesis Cornea Development In Camera-type Eye Positive Regulation Of Core Promoter Binding	Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis	Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP) Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Body mass index ( 22344219 28892062) Depression ( 29700475) Diastolic blood pressure ( 27841878) Feeling worry ( 29500382) General factor of neuroticism ( 30867560) Irritable mood ( 29500382) Major depressive disorder ( 27479909) Neurociticism ( 29500382) Optic disc area ( 28073927) Refractive error ( 32231278) Systolic blood pressure ( 27841878)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		126 interacting genes: ACOT12 AP1M1 ARIH2 ATP6V0D2 ATP6V1C2 BANP BCL2L15 C1orf109 C2CD6 CCDC103 CCDC6 CCL26 CDK3 CDX2 CGGBP1 CHAF1A CIB3 CINP CKS1B CSNK2A1 CTNNA3 CXorf38 DHPS DIAPH1 DLG1 DYNLL1 EAF1 EFHC1 EIF1AD EN1 EP300 ESRRG FAM50B GAS2L2 GCM2 GEMIN2 GPANK1 GRHL2 HGS HIPK2 HMBOX1 HMGB3 HNRNPC HOMER3 HOXA1 HOXB1 HOXC8 HOXC9 IPO13 KANK2 KCTD7 KRTAP9-3 KRTAP9-8 LARP4 LHX2 LNPK LONRF1 LXN LYSMD1 MAFG MAPRE1 MFAP1 MID1 MIPOL1 MISP MITF MORN3 MRPL53 NCDN NFKBID NFYC NGLY1 NKIRAS2 PATJ PBX1 PDE4C PICK1 PIN1 PKNOX1 POLR3C POLR3GL PPIL4 PRKAG1 PROX1 PSORS1C2 QRICH1 RANBP3 RAX RB1 RGS3 RNF111 SAE1 SEC14L4 SET SHANK3 SIGLEC6 SIX3 SLC12A8 SMARCA4 SOX10 SOX3 SPDYC SPG21 SRSF11 STAC SUMO1 TBP TCP11L1 THOC1 TLK1 TLK2 TRAPPC6A TRIM11 TRIP10 UBE2F UBE2K UBE3A UBXN2B UBXN7 USHBP1 VCX2 VSX2 WASHC3 ZBED1 ZNF124 ZNF410	28 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LDB1 LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511
Entrez ID		5080	9355
HPRD ID		06167	04786
Ensembl ID		ENSG00000007372	ENSG00000106689
Uniprot IDs		A0A1W2PRA8 D1KF47 F1T0F8 P26367 Q66SS1	B3KNJ5 P50458
PDB IDs		2CUE 6PAX
Enriched GO Terms of Interacting Partners?
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