REG3A and SDC2

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		REG3A	SDC2
Description		regenerating family member 3 alpha	syndecan 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Peptidoglycan Binding Oligosaccharide Binding	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Acute-phase Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Antimicrobial Humoral Response Response To Peptide Hormone Cell Wall Disruption In Other Organism Negative Regulation Of Keratinocyte Differentiation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Biological_process Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis Leukocyte Migration
Pathways		Antimicrobial peptides	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport
Drugs			Sargramostim
Diseases
GWAS		Body mass index ( 25673413)	Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: ANXA3 FN1 MDFI REG1A SDC2 TRHDE	28 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		5068	6383
HPRD ID		01342	00803
Ensembl ID		ENSG00000172016	ENSG00000169439
Uniprot IDs		Q06141 Q53S56	A0A024R9D1 E9PBI9 P34741
PDB IDs		1UV0 2GO0 4MTH	6ITH
Enriched GO Terms of Interacting Partners?
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