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PAK1 and FLNA
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
PAK1
FLNA
Description
p21 (RAC1) activated kinase 1
filamin A
Image
GO Annotations
Cellular Component
Ruffle
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Extracellular Region
Nucleus
Nucleolus
Cytoplasm
Trans-Golgi Network
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Z Disc
Cortical Cytoskeleton
Myb Complex
Actin Filament Bundle
Dendritic Shaft
Perikaryon
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Apical Dendrite
Postsynapse
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Protein Kinase Binding
Small GTPase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
G Protein-coupled Receptor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Kinase Binding
Small GTPase Binding
Mu-type Opioid Receptor Binding
Fc-gamma Receptor I Complex Binding
Protein Homodimerization Activity
Ion Channel Binding
Cadherin Binding
SMAD Binding
Actin Filament Binding
GTPase Binding
Biological Process
MAPK Cascade
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Protein Phosphorylation
Exocytosis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Fibroblast Migration
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Positive Regulation Of Cell Migration
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Microtubule Polymerization
T Cell Costimulation
Actin Cytoskeleton Reorganization
Activation Of Protein Kinase Activity
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
T Cell Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Angiogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Platelet Degranulation
Heart Morphogenesis
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Transcription By RNA Polymerase I
Formation Of Radial Glial Scaffolds
Cerebral Cortex Development
Platelet Activation
Regulation Of Cell Migration
Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Filament Bundle Assembly
Cell Junction Assembly
Protein Localization To Cell Surface
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Import Into Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA-binding Transcription Factor Activity
Wound Healing, Spreading Of Cells
Early Endosome To Late Endosome Transport
Establishment Of Protein Localization
Cell-cell Junction Organization
Positive Regulation Of Axon Regeneration
Synapse Organization
Protein Stabilization
Cytoplasmic Sequestering Of Protein
Defense Response To Virus
Actin Crosslink Formation
Cilium Assembly
Platelet Aggregation
Semaphorin-plexin Signaling Pathway
Protein Localization To Plasma Membrane
Tubulin Deacetylation
Mitotic Spindle Assembly
Establishment Of Sertoli Cell Barrier
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Potassium Ion Transmembrane Transport
Protein Localization To Bicellular Tight Junction
Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential
Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Integrin-mediated Signaling Pathway
Positive Regulation Of Neuron Migration
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
Platelet degranulation
GP1b-IX-V activation signalling
Cell-extracellular matrix interactions
RHO GTPases activate PAKs
OAS antiviral response
Drugs
Fostamatinib
Artenimol
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
Periventricular nodular heterotopia (PVNH)
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Immature fraction of reticulocytes (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
85 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BMPR1B
BMX
BRSK1
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
98 interacting genes:
ADAMTSL4
APC
AR
ARHGAP24
ARRB1
ARRB2
ASB2
BRCA1
BRCA2
CALCR
CAMK2G
CASR
CAV1
CCNB1
CDC42
CEACAM1
CMIP
DCN
DDIT4L
DRD1
DRD2
DRD3
DUX4
ERBB3
F3
FABP1
FBLIM1
FILIP1
FLNB
FURIN
GP1BA
GRIK1
GRIK3
GRM4
GRM5
GRM7
GRM8
HHLA3
HNRNPD
HSPA6
HSPB7
ITGB1
ITGB3
ITGB5
ITGB6
ITGB7
KCNE4
KCNJ2
KLHL12
LGALS14
LMNA
MAP2K4
MAPK14
MCPH1
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
NLGN3
NPHP1
OPRM1
PAK1
PCBP2
PELO
PHOSPHO2
PLEKHF2
PRKCA
PSEN1
PSEN2
RAC1
RALA
REL
RFLNA
RHOA
SELE
SH2B3
SHBG
SIGLEC10
SIRPA
SMAD3
SMAD5
SPANXD
SRC
SUMO2
SVIL
SYNPO2
TCF4
TLR10
TNIP2
TP73
TRAF2
TRIM55
TRIO
TTN
USP19
VHL
YWHAG
Entrez ID
5058
2316
HPRD ID
03995
02060
Ensembl ID
ENSG00000149269
ENSG00000196924
Uniprot IDs
A0A024R5P0
Q13153
P21333
Q60FE5
Q6NXF2
PDB IDs
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
2AAV
2BP3
2BRQ
2J3S
2JF1
2K3T
2K7P
2K7Q
2MTP
2W0P
2WFN
3CNK
3HOC
3HOP
3HOR
3ISW
3RGH
4M9P
4P3W
5XR1
6D8C
6EW1
Enriched GO Terms of Interacting Partners
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