PAEP and AQP9

Data Source:
BioGRID (two hybrid)

		PAEP	AQP9
Description		progestagen associated endometrial protein	aquaporin 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Small Molecule Binding	Amine Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transporter Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Water Transmembrane Transporter Activity Protein Binding Polyol Transmembrane Transporter Activity Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Urea Channel Activity Carboxylic Acid Transmembrane Transporter Activity
	Biological Process	Apoptotic Process Multicellular Organism Development Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Sperm Capacitation Regulation Of Binding Of Sperm To Zona Pellucida	Water Transport Purine Nucleobase Transport Response To Osmotic Stress Excretion Response To Organic Substance Canalicular Bile Acid Transport Polyol Transport Glycerol Transport Amine Transport Pyrimidine Nucleobase Transport Water Homeostasis Response To Mercury Ion Carboxylic Acid Transport Cellular Response To CAMP Urea Transmembrane Transport Pyrimidine-containing Compound Transmembrane Transport Purine Nucleobase Transmembrane Transport Carboxylic Acid Transmembrane Transport
Pathways			Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins
Drugs		12-Bromododecanoic Acid Palmitic Acid Glycerin
Diseases
GWAS			Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Ischemic stroke ( 26089329) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 23823483 22916037) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		22 interacting genes: A2M APP AQP6 AQP9 ARL13B COPS6 EEF1A1 ERVFRD-1 GORAB GPR42 GPX8 GRAMD2B HIBADH IFNLR1 IGSF21 LRIF1 PCDHGA4 PTPRC SMAD3 TMX2 UBE2E1 XRCC6	24 interacting genes: ADAM33 AIG1 APOD CCDC167 CLDN19 CPLX4 CTXN3 CXCL16 EMC6 FATE1 FXYD3 FZD7 GAST HHLA2 IGFBP5 LHFPL5 MIP PAEP SERINC1 SGPL1 SLC38A7 TF TMED9 TMEM109
Entrez ID		5047	366
HPRD ID		01411	04223
Ensembl ID		ENSG00000122133	ENSG00000103569
Uniprot IDs		A0A024R8D8 A6XNE0 B2R4F9 B4E3C0 P09466	H0YK62 O43315
PDB IDs		4R0B
Enriched GO Terms of Interacting Partners?
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