ORC1 and ORC3

Data Source:
HPRD (in vitro)

		ORC1	ORC3
Description		origin recognition complex subunit 1	origin recognition complex subunit 3
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Nuclear Body DNA Replication Preinitiation Complex
	Molecular Function	DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding ATPase Activity Metal Ion Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint	G1/S Transition Of Mitotic Cell Cycle DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication Neural Precursor Cell Proliferation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		23 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RPA2 SKP2 XPO1	21 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 DBF4 FBXO7 H3-4 H4-16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2
Entrez ID		4998	23595
HPRD ID		03544	05398
Ensembl ID		ENSG00000085840	ENSG00000135336
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q9UBD5
PDB IDs		5UJ7 5UJM 6P3W 7JPO 7JPP 7JPR 7JPS	5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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