FXYD2 and SLC22A1

Data Source:
BioGRID (protein complementation assay)

		FXYD2	SLC22A1
Description		FXYD domain containing ion transport regulator 2	solute carrier family 22 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Presynapse
	Molecular Function	ATPase Activator Activity Sodium Channel Regulator Activity Protein-macromolecule Adaptor Activity Ion Channel Regulator Activity	Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity
	Biological Process	Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Transmembrane Transport Positive Regulation Of Sodium:potassium-exchanging ATPase Activity Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane Regulation Of Sodium Ion Transmembrane Transporter Activity	Neurotransmitter Transport Drug Transmembrane Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Serotonin Uptake Norepinephrine Uptake Pyrimidine-containing Compound Transmembrane Transport Dopamine Uptake Cation Transmembrane Transport Transport Across Blood-brain Barrier Acetate Ester Transport Toxin Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs		Cyclothiazide Thimerosal
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965) Refractive error ( 32231278)	Apolipoprotein B levels ( 32203549) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Essential hypertension (time to event) ( 32589924) Gout ( 22179738) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol levels ( 32203549) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipoprotein (a) levels ( 26377243) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic traits ( 21886157) Prostate cancer ( 26034056 21743057) Serum metabolite levels ( 23093944) Triglyceride levels ( 32203549) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995)
Interacting Genes		5 interacting genes: ATP1A1 ERGIC3 SGTA SLC22A1 SLC22A2	27 interacting genes: ALDOA CAPN1 CCL2 CD63 CD9 CERS2 CHST12 CLPTM1 CYSTM1 FIS1 FXYD2 GHITM KRTCAP2 LAPTM4A LAPTM4B MUC1 PDZK1IP1 POU2AF1 SERP1 SLC25A11 SMIM24 SMIM3 SPP1 TMBIM4 TMEM147 TMEM179B VAPB
Entrez ID		486	6580
HPRD ID		03487	04007
Ensembl ID		ENSG00000137731	ENSG00000175003
Uniprot IDs		P54710	O15245
PDB IDs		2MKV
Enriched GO Terms of Interacting Partners?
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