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CNOT2 and NCOR1
Data Source:
BioGRID
(two hybrid)
CNOT2
NCOR1
Description
CCR4-NOT transcription complex subunit 2
nuclear receptor corepressor 1
Image
GO Annotations
Cellular Component
P-body
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
CCR4-NOT Complex
CCR4-NOT Core Complex
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Membrane
Sin3 Complex
Transcription Repressor Complex
Mitotic Spindle
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Transcription Coregulator Activity
Poly(A)-specific Ribonuclease Activity
Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Corepressor Activity
Protein Binding
Nuclear Hormone Receptor Binding
Histone Deacetylase Binding
Thyroid Hormone Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Trophectodermal Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Regulation Of Translation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
Gene Silencing By RNA
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Circadian Rhythm
Regulation Of Lipid Metabolic Process
Locomotor Rhythm
Negative Regulation Of Glycolytic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Fatty Acid Metabolic Process
Negative Regulation Of JNK Cascade
Spindle Assembly
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (age of onset) (
22959728
)
Diastolic blood pressure (
27841878
)
Ovarian cancer (
30557369
)
Triglyceride levels (
32154731
)
Adult body size (
32376654
)
C-reactive protein levels (
30388399
)
FEV1 (
30804560
)
Free thyroxine concentration (
30367059
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
30804560
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
26 interacting genes:
ARMC5
BCL6
BEX1
C11orf1
C20orf85
CCHCR1
CNOT1
CNOT3
CNOT4
CNOT8
CSTF2
DDB1
GALNT10
GCSAM
GPS1
GPS2
HSF2BP
MTFR1L
NCOR1
NCOR2
PRR35
PSMB4
RACK1
TBX2
TEKT3
ZFHX3
89 interacting genes:
ACTN2
AR
ATXN1
ATXN1L
ATXN3
BCL6
C1D
CBFA2T2
CHD1
CHUK
CLK1
CNOT2
COPS2
CSNK2A1
CXADR
DACH1
DDX20
DHX30
DZIP3
ENO1
ESR1
ESR2
ETS1
ETS2
GPS2
GTF2B
H3C1
H4C1
HDAC3
HDAC5
HDAC9
HESX1
HEY2
HTT
KLF5
MECP2
MYB
MYBL2
MYOD1
NCOA1
NCOA3
NCOR2
NELFE
NR1D1
NR1D2
NR1H2
NR1H3
NR2E3
NR3C1
NR6A1
PDCD2
PHB
PIAS1
PML
POU1F1
PPARA
PPARD
PPARG
PTMA
RARA
RARG
RBPJ
RUNX1
RUNX1T1
RXRA
SAFB
SAP30
SKI
SKIL
SNW1
SP1
SPEN
SQSTM1
SUMO2
TAB2
TAF6
TAF9
TBL1X
TBL1XR1
THRA
THRB
TRIM14
TULP3
TXNRD2
VDR
ZBTB16
ZBTB33
ZBTB7A
ZMYND11
Entrez ID
4848
9611
HPRD ID
05367
02911
Ensembl ID
ENSG00000111596
ENSG00000141027
Uniprot IDs
A0A024RBD8
B2RDX7
B3KTL6
F8VUB4
F8VV52
Q9NZN8
A0A024RD47
O75376
Q6PGR4
PDB IDs
4C0D
4C0F
5FU6
5FU7
2EQR
3H52
3KMZ
3N00
4MDD
4WVD
6ONI
Enriched GO Terms of Interacting Partners
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