NMB and TPP1

Data Source:
HPRD (in vitro)

		NMB	TPP1
Description		neuromedin B	tripeptidyl peptidase 1
Image
GO Annotations	Cellular Component	Extracellular Region Neuron Projection	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuromedin B Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Glucose Homeostasis Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonic Acid Secretion	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation IRE1-mediated Unfolded Protein Response Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	XBP1(S) activates chaperone genes
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) P wave terminal force ( 28794112) Schizophrenia ( 29483656)	Malaria ( 31844061)
Interacting Genes		4 interacting genes: BIRC2 GADD45G NMBR TPP1	6 interacting genes: CTC1 NMB POT1 STN1 TERT TINF2
Entrez ID		4828	1200
HPRD ID		01210	06415
Ensembl ID		ENSG00000197696	ENSG00000166340
Uniprot IDs		P08949	O14773
PDB IDs		1C98 1C9A	1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?
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