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NF2 and GRM1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
NF2
GRM1
Description
neurofibromin 2
glutamate metabotropic receptor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Membrane
Lamellipodium
Cortical Actin Cytoskeleton
Filopodium Membrane
Cleavage Furrow
Ruffle Membrane
Neuron Projection
Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Nucleus
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
G Protein-coupled Receptor Dimeric Complex
G Protein-coupled Receptor Homodimeric Complex
Schaffer Collateral - CA1 Synapse
Postsynaptic Density Membrane
Glutamatergic Synapse
Molecular Function
Actin Binding
Protein Binding
Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity
G Protein-coupled Receptor Activity
Protein Binding
Glutamate Receptor Activity
G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential
Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Biological Process
Mesoderm Formation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Ectoderm Development
Negative Regulation Of Cell Population Proliferation
Schwann Cell Proliferation
Regulation Of Gliogenesis
Hippocampus Development
Negative Regulation Of Cell-cell Adhesion
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Regulation Of Protein Stability
Regulation Of Hippo Signaling
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Lens Fiber Cell Differentiation
Regulation Of Stem Cell Proliferation
Regulation Of Protein Localization To Nucleus
Regulation Of Neural Precursor Cell Proliferation
Activation Of MAPKK Activity
Activation Of MAPK Activity
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Glutamate Receptor Signaling Pathway
Chemical Synaptic Transmission
Locomotory Behavior
Sensory Perception Of Pain
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Regulation Of Sensory Perception Of Pain
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Postsynaptic Membrane Potential
Cellular Response To Electrical Stimulus
L-glutamate Import Across Plasma Membrane
Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases activate PAKs
G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Neurexins and neuroligins
Neurexins and neuroligins
Drugs
Glutamic acid
(S)-alpha-methyl-4-carboxyphenylglycine
Diseases
Malignant pleural mesothelioma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Carotid atherosclerosis in HIV infection (
20009918
)
Cerebral amyloid deposition (PET imaging) (
26252872
)
Suicide (
31476763
)
Waist circumference (
29212154
)
Interacting Genes
74 interacting genes:
AGAP2
AKT1
AMOT
AMOTL2
ARAF
ARNT
AURKA
BDKRB1
BECN1
BYSL
CBLC
CCNB1IP1
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
CTNNB1
DACH1
DCAF1
EGFR
EIF3B
EMD
EPHA2
ERBB2
EZR
FGFR4
FZR1
GLIS2
GRM1
HGF
HGS
HIF1A
IGF1R
ITGB1
KAT2A
KDELR2
KDM1A
LATS1
LATS2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MDM4
MED28
MET
MYBPC2
MYC
PAK1
PDGFRA
PRKCA
PXN
PYGO2
RAF1
RALGDS
RASSF1
SCHIP1
SDCBP
SGSM3
SLC9A3R1
SOX3
SOX4
SPTBN1
STK11
TARBP2
TERT
TP53
TSC1
TTYH2
TXLNB
XPO1
40 interacting genes:
ADORA1
BECN1
CABIN1
CASR
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2B
CDKN2C
EFNB2
EPB41L2
EPHA2
ERBB2
FGFR4
GAPDH
GPRASP1
GRK2
HOMER1
HOMER2
IGF1R
ITPR1
KAT2A
KDELR2
LATS2
MAP2K5
MYC
NF2
OPRM1
OPTN
PDGFRA
PRKCA
RAF1
RASSF1
STK11
TAMALIN
TERT
TTYH2
TUBB
Entrez ID
4771
2911
HPRD ID
06980
05129
Ensembl ID
ENSG00000186575
ENSG00000152822
Uniprot IDs
A0A024R1D9
A0A024R1F6
A0A024R1I0
A0A024R1J8
A0A024R1J9
P35240
Q13255
Q59HC2
PDB IDs
1H4R
3U8Z
4ZRI
4ZRJ
6CDS
3KS9
4OR2
Enriched GO Terms of Interacting Partners
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