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NEK2 and PPP1CC
Data Source:
BioGRID
(far western blotting, two hybrid)
NEK2
PPP1CC
Description
NIMA related kinase 2
protein phosphatase 1 catalytic subunit gamma
Image
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome
Spindle Pole
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Microtubule
Midbody
Protein-containing Complex
Protein Phosphatase Type 1 Complex
Condensed Chromosome Kinetochore
Chromosome, Telomeric Region
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Focal Adhesion
Nuclear Speck
Midbody
Cleavage Furrow
Protein-containing Complex
Dendritic Spine
PTW/PP1 Phosphatase Complex
Presynapse
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Lamin Binding
Protein C-terminus Binding
Protein Phosphatase 1 Binding
Phosphatase Activity
Protein Kinase Binding
Protein Domain Specific Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein N-terminus Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Blastocyst Development
Protein Phosphorylation
Chromosome Segregation
Regulation Of Mitotic Nuclear Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Binding
Regulation Of Mitotic Centrosome Separation
Protein Autophosphorylation
Spindle Assembly
Centrosome Separation
Cell Division
Meiotic Cell Cycle
Positive Regulation Of Telomerase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic Spindle Assembly
Ciliary Basal Body-plasma Membrane Docking
Negative Regulation Of Centriole-centriole Cohesion
Positive Regulation Of Telomere Capping
Glycogen Metabolic Process
Protein Dephosphorylation
Cell Cycle
Neuron Differentiation
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Regulation Of Nucleocytoplasmic Transport
Cell Division
Positive Regulation Of Glial Cell Proliferation
Pathways
APC-Cdc20 mediated degradation of Nek2A
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Triglyceride catabolism
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Circadian Clock
RHO GTPases Activate Formins
RAF activation
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Signaling by MRAS-complex mutants
Drugs
5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide
Fostamatinib
9,10-Deepithio-9,10-Didehydroacanthifolicin
Calyculin A
Motuporin
Diseases
GWAS
Red cell distribution width (
32888494
27863252
28957414
)
Heart rate (
23583979
)
Interacting Genes
28 interacting genes:
CCDC85A
CDC20
CEP250
CHGA
CSN2
CTNNB1
DCTN1
EDRF1
EIF4A2
FZR1
GIT1
IFT140
IMMT
MAD1L1
MAPK1
MCC
NDC80
NEK11
PDE4DIP
PPP1CA
PPP1CC
PPP1R2
PRKN
PTPRD
SMURF1
SPTBN4
TCF25
TPM3
131 interacting genes:
AATK
ABT1
ACAD8
AKAP11
ANKRD42
APIP
APP
ASH2L
AURKA
B4GAT1
BMPR2
BTBD10
C14orf180
C1QA
C9orf50
CEP126
CLMN
CLOCK
CLTC
CNST
COPS5
CSNK1A1
CSNK1E
CSNK2B
CSRNP1
CSRNP2
CTSL
CYFIP1
DACT1
DEAF1
DELEC1
DYNLT4
DYRK4
EIF2AK2
ELP4
ENKD1
FBXW11
FTL
FXYD6
GLB1L
GOLGA7
GSTZ1
HCFC1
HDAC6
HMGN1
IFTAP
IL3RA
INSYN1
JAK2
KCTD20
KDM4D
KRCC1
LMTK2
MAP4K4
MAPT
MYO16
NAPEPLD
NEK2
NMT2
NONO
NRBP1
NUAK1
PHACTR4
PHC1
PIAS1
POLR1F
PPP1R11
PPP1R15B
PPP1R16A
PPP1R18
PPP1R2
PPP1R2B
PPP1R2C
PPP1R32
PPP1R35
PPP1R3A
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R7
PPP1R8
PPP1R9A
PPP1R9B
PPP2R5C
PRR16
RAF1
RB1
RIF1
RNF19B
RORC
RPL7
RPRD2
RRM1
RRP1B
SDR39U1
SFRP1
SGCE
SH3RF2
SHANK3
SMARCB1
SMG6
SPATC1L
SPOCD1
STAM
STARD9
STAU1
SUMO2
TACC2
TBC1D19
TEFM
TEX36
TLX1
TLX3
TMEM120A
TNS1
TOPBP1
TOR1AIP1
TP53
TP53BP2
TPRN
TRA2A
VSTM4
WBP11
YLPM1
YWHAZ
ZDBF2
ZFYVE9
ZNF24
ZNF318
ZNF629
ZNF667
Entrez ID
4751
5501
HPRD ID
04953
08911
Ensembl ID
ENSG00000117650
ENSG00000186298
Uniprot IDs
F6U4U2
P51955
A0A024RBP2
P36873
PDB IDs
2JAV
2W5A
2W5B
2W5H
2WQO
2XK3
2XK4
2XK6
2XK7
2XK8
2XKC
2XKD
2XKE
2XKF
2XNM
2XNN
2XNO
2XNP
4A4X
4AFE
5M51
5M53
5M55
5M57
6SGD
6SGH
6SGI
6SGK
6SK9
6TM5
1IT6
1JK7
1U32
2BCD
2BDX
4UT2
4UT3
5INB
5J28
Enriched GO Terms of Interacting Partners
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