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NEDD8 and COPS5
Data Source:
BioGRID
(pull down)
NEDD8
COPS5
Description
NEDD8 ubiquitin like modifier
COP9 signalosome subunit 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Synaptic Vesicle
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Transcription Coactivator Activity
Translation Initiation Factor Activity
Metalloendopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
NEDD8-specific Protease Activity
Enzyme Binding
Macrophage Migration Inhibitory Factor Binding
Metal Ion Binding
Isopeptidase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Cellular Protein Modification Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Cellular Iron Ion Homeostasis
Protein Localization
Anatomical Structure Morphogenesis
Response To Organic Cyclic Compound
Protein Ubiquitination
Protein Deubiquitination
Modification-dependent Protein Catabolic Process
Regulation Of Proteolysis
Post-translational Protein Modification
Protein Neddylation
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
Translation
Translational Initiation
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of IRE1-mediated Unfolded Protein Response
Exosomal Secretion
Pathways
TGF-beta receptor signaling activates SMADs
UCH proteinases
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Iron uptake and transport
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Diseases
GWAS
Mean corpuscular volume (
29403010
)
Systolic blood pressure (cigarette smoking interaction) (
26752167
)
Interacting Genes
42 interacting genes:
AHR
ARIH2
ATXN3
CBLB
CDC34
COPS5
COPS6
CTRC
CUL1
CUL2
CUL3
CUL4B
DNMT3B
GARS1
GHR
HGS
HIF1A
HSPA4
N4BP1
NAE1
NUB1
OTUB1
OTUD5
PARP1
POLI
PSMA6
PSMD4
PTK2
RAD23A
SENP8
SMURF1
TP53
UBA2
UBA3
UBE2K
UBE2M
UBL7
UBQLN1
UBXN7
UCHL1
UCHL3
YAF2
98 interacting genes:
APCS
ARFGAP1
ATM
ATRN
BCL2L14
BCL3
BRD4
BRSK2
CACNA1C
CD274
CD93
CDKN1B
CENPT
CHUK
COPS2
COPS3
COPS4
COPS6
COPS7A
COPS7B
COPS8
COPS9
CUL1
CUL2
CUL3
CUL4A
CUL5
DDB1
DDO
ERN1
ERRFI1
ESR1
F2RL1
GFER
GFI1B
GPS1
GTPBP3
HAND2
HIF1A
HNF4A
HNF4G
HTR6
ITGB2
JUN
JUND
LASP1
MAP2K2
MAP3K11
MAP3K3
MAP3K7
MAP4K3
MAP4K5
MAPK14
MAPRE1
MAX
MDC1
MDM2
MEF2C
MEF2D
MIF
MTRES1
MYG1
NCOA1
NEDD8
NFKB1
NR4A2
NR4A3
OPRM1
PEA15
PGR
PLAC8
PPARG
PPOX
PPP1CC
PRDX2
PRKD1
PTGS2
RAD1
RAD9A
RNF139
RORA
S100A7
SHANK3
SHISA5
SMAD2
SMAD4
SMAD5
SPP1
SREBF2
TOP2A
TP53
TXN
TYK2
UCHL1
USP14
VTN
WNK1
YWHAG
Entrez ID
4738
10987
HPRD ID
04412
06888
Ensembl ID
ENSG00000129559
ENSG00000121022
Uniprot IDs
Q15843
A0A024R7W9
Q92905
PDB IDs
1NDD
1R4M
1R4N
1XT9
2BKR
2KO3
2N7K
2NVU
3DBH
3DBL
3DBR
3DQV
3GZN
4F8C
4FBJ
4HCP
4P5O
6R7F
6R7I
6TTU
4D10
4D18
4F7O
4WSN
5JOG
5JOH
5M5Q
6R6H
6R7F
6R7H
6R7I
Enriched GO Terms of Interacting Partners
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