NDUFS6 and KCNH2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NDUFS6	KCNH2
Description		NADH:ubiquinone oxidoreductase subunit S6	potassium voltage-gated channel subfamily H member 2
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GO Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity C3HC4-type RING Finger Domain Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Respiratory Chain Complex I Assembly	Regulation Of Heart Rate By Hormone Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Respiratory electron transport Complex I biogenesis	Voltage gated Potassium channels Phase 3 - rapid repolarisation
Drugs		NADH	Fluvoxamine Erythromycin Dofetilide Enflurane Phenytoin Amsacrine Disopyramide Ibutilide Amitriptyline Terfenadine Alfuzosin Loratadine Prazosin Imipramine Fluoxetine Chlorpromazine Sotalol Ciprofloxacin Hydroxyzine Doxazosin Cisapride Astemizole Verapamil Tamoxifen Thioridazine Quinidine Ketoconazole Procainamide Promethazine Perhexiline Pimozide Miconazole Amiodarone Carvedilol Doxepin Nefazodone Terazosin Propafenone Flecainide Clarithromycin Halofantrine Bepridil Dronedarone Azimilide Sertindole Vernakalant Tecastemizole Potassium nitrate Pentoxyverine Chlorobutanol Isavuconazole Pitolisant
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Short QT syndrome
GWAS		Lack of perseverance ( 30718321) Metabolite levels ( 23823483)	Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronotype ( 30696823) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062061 20062063) Eyebrow thickness ( 26926045) Metabolic syndrome ( 31589552) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409 29874175) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560)
Interacting Genes		5 interacting genes: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2	11 interacting genes: ALG10 ALG10B CDC73 FRMD8 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		4726	3757
HPRD ID		10356	01069
Ensembl ID		ENSG00000145494	ENSG00000055118
Uniprot IDs		O75380 Q6IBC4	A0A090N7W1 A0A090N7X5 A0A090N8Q0 Q12809 Q15BH2
PDB IDs		5XTB 5XTD 5XTH 5XTI	1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 2N7G 4HP9 4HQA 5VA1 5VA2 5VA3 6SYG
Enriched GO Terms of Interacting Partners?
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