NDUFB8 and PFN2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NDUFB8	PFN2
Description		NADH:ubiquinone oxidoreductase subunit B8	profilin 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Endoplasmic Reticulum Integral Component Of Membrane	Cytoplasm Cytoskeleton Extracellular Exosome
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Respiratory Chain Complex I Assembly	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Mitochondrial protein import Mitochondrial protein import Respiratory electron transport Complex I biogenesis	Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		NADH	Triglyme Pentaglyme
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Palmitoleic acid (16:1n-7) levels ( 23362303)	Fish- and plant-related diet ( 32066663)
Interacting Genes		6 interacting genes: ATP6V0D2 CACNA1A EIF2B3 PFN2 PIM2 ZAP70	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		4714	5217
HPRD ID		11886	01451
Ensembl ID		ENSG00000166136	ENSG00000070087
Uniprot IDs		O95169	P35080
PDB IDs		5XTC 5XTD 5XTH 5XTI	1D1J
Enriched GO Terms of Interacting Partners?
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