NBN and VRK1

Data Source:
BioGRID (enzymatic study)

		NBN	VRK1
Description		nibrin	VRK serine/threonine kinase 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Spindle Cytosol
	Molecular Function	Damaged DNA Binding Protein Binding Transcription Factor Binding Protein N-terminus Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Nucleosomal Histone Binding Histone Kinase Activity (H3-S10 Specific) Histone Kinase Activity (H3-T3 Specific) Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Blastocyst Growth DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Cell Population Proliferation Viral Process Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Signal Transduction In Response To DNA Damage Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Telomere Capping	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Peptidyl-serine Phosphorylation Histone H3-S10 Phosphorylation Protein Autophosphorylation Cell Division Histone H3-T3 Phosphorylation Golgi Disassembly
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	Pontocerebellar hypoplasia
GWAS		Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494)	Bone ultrasound measurement (velocity of sound) ( 28472463) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive function ( 24684796) Copper levels ( 26025379) Fractures (paediatric) ( 32742401) Metabolite levels ( 23823483) Neutrophil count ( 21507922) Night sleep phenotypes ( 27126917) Staphylococcus aureus infection ( 24847357)
Interacting Genes		35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NAT2 NCL PRKDC RAD18 RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5	6 interacting genes: H2BC21 H3C14 NBN PLK3 SRPK2 TP53
Entrez ID		4683	7443
HPRD ID		04050	03701
Ensembl ID		ENSG00000104320	ENSG00000100749
Uniprot IDs		A0A0C4DG07 O60934	Q99986
PDB IDs		5WQD	2KTY 2KUL 2LAV 2RSV 3OP5 5UKF 5UVF 6AC9 6BP0 6BRU 6BTW 6BU6 6CFM 6CMM 6CNX 6CQH 6CSW 6DD4 6NPN 6VZH
Enriched GO Terms of Interacting Partners?
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