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MYOC and LAMA5
Data Source:
HPRD
(two hybrid)
MYOC
LAMA5
Description
myocilin
laminin subunit alpha 5
Image
GO Annotations
Cellular Component
Extracellular Space
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Cilium
Cytoplasmic Vesicle
Node Of Ranvier
Collagen-containing Extracellular Matrix
Extracellular Exosome
Extracellular Region
Basement Membrane
Laminin-5 Complex
Extracellular Space
Nucleus
Neuromuscular Junction
Synaptic Cleft
Laminin-10 Complex
Laminin-11 Complex
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Fibronectin Binding
Frizzled Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Myosin Light Chain Binding
Metal Ion Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Biological Process
Osteoblast Differentiation
Negative Regulation Of Cell-matrix Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Skeletal Muscle Hypertrophy
Myelination In Peripheral Nervous System
Positive Regulation Of Cell Migration
Neuron Projection Development
Negative Regulation Of Rho Protein Signal Transduction
Non-canonical Wnt Signaling Pathway Via JNK Cascade
ERBB2-ERBB3 Signaling Pathway
Regulation Of MAPK Cascade
Clustering Of Voltage-gated Sodium Channels
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Mitochondrial Depolarization
Bone Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Branching Involved In Ureteric Bud Morphogenesis
Morphogenesis Of A Polarized Epithelium
Neural Crest Cell Migration
Hair Follicle Development
Integrin-mediated Signaling Pathway
Axon Guidance
Muscle Organ Development
Animal Organ Morphogenesis
Tissue Development
Morphogenesis Of Embryonic Epithelium
Cell Migration
Cytokine-mediated Signaling Pathway
Regulation Of Cell Adhesion
Extracellular Matrix Organization
Lung Development
Regulation Of Cell Migration
Substrate Adhesion-dependent Cell Spreading
Regulation Of Cell Population Proliferation
Odontogenesis Of Dentin-containing Tooth
Regulation Of Embryonic Development
Cilium Assembly
Branching Involved In Salivary Gland Morphogenesis
Protein Localization To Plasma Membrane
Cell-cell Adhesion
Pathways
Degradation of the extracellular matrix
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Interleukin-4 and Interleukin-13 signaling
MET activates PTK2 signaling
Drugs
Lanoteplase
Diseases
Primary open angle glaucoma
GWAS
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Glaucoma (
30104761
)
Intake of total sugars (
31005972
)
Blood protein levels (
29875488
)
Colorectal cancer (
25990418
20972440
24737748
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31152163
)
Neuroblastoma (pediatric) (
32599975
)
Pelvic organ prolapse (
26545240
)
Plateletcrit (
32888494
)
Prostate cancer (
23535732
)
Interacting Genes
41 interacting genes:
A2M
ACTA2
ACTB
ACTG1
ALDOA
ANXA2
C1QB
CAP1
CD81
CKM
CLIC1
COL1A2
COL3A1
ECE1
EEF1A1
ENO1
FBN1
FN1
FTL
FUBP1
GAPDH
GGTLC1
HAGH
IGLL1
ITGA7
LAMA5
LGALS3
MAEA
MYL2
NOTCH2
OLFM3
OLFML3
PKLR
PKM
RFC1
SERPINF1
SGTA
TGFBR1
TIMP1
TKT
TNFRSF1A
15 interacting genes:
ATF7IP
BCAM
BTBD10
COL7A1
CRKL
DAG1
FBLN2
LAMC1
MEP1A
MTDH
MYOC
SMAD2
SV2A
UBC
USP4
Entrez ID
4653
3911
HPRD ID
03387
03020
Ensembl ID
ENSG00000034971
ENSG00000130702
Uniprot IDs
A0A0S2Z421
Q99972
O15230
PDB IDs
4WXQ
4WXS
4WXU
6OU0
6OU1
6OU2
6OU3
6PKD
6PKE
6PKF
5XAU
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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