MYCN and HUWE1

Data Source:
BioGRID (enzymatic study)

		MYCN	HUWE1
Description		MYCN proto-oncogene, bHLH transcription factor	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Protein Polyubiquitination Base-excision Repair Protein Monoubiquitination Golgi Organization Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Histone Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neutrophil Degranulation Positive Regulation Of Protein Catabolic Process Membrane Fusion Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Neuroblastoma Feingold syndrome	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Lymphocyte counts ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)	Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)
Interacting Genes		20 interacting genes: CSNK2A1 CSNK2A2 DOT1L EZH2 FBXW7 GRSF1 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 YAF2 YBX1 YEATS4 ZBTB17	36 interacting genes: ABL1 ATOH1 CALM1 CCL1 CDKN2A CTNNB1 CUL4B ERG H2AX HDAC2 HSPB1 LAPTM5 MCL1 MYCN PCNA PIAS2 POLB POLL PPP5C RBBP7 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2L3 USP4 USP7 WBP2
Entrez ID		4613	10075
HPRD ID		01278	06608
Ensembl ID		ENSG00000134323	ENSG00000086758
Uniprot IDs		A0A1W2PPD9 P04198 Q9H224	A0A024R9W5 Q7Z6Z7
PDB IDs		5G1X	2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL
Enriched GO Terms of Interacting Partners?
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