MVK and SELPLG

Data Source:
HPRD (in vivo)

		MVK	SELPLG
Description		mevalonate kinase	selectin P ligand
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GO Annotations	Cellular Component	Peroxisome Cytosol Intracellular Membrane-bounded Organelle	Uropod Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Plasma Membrane Raft
	Molecular Function	Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Virus Receptor Activity Signaling Receptor Binding Protein Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Inflammatory Response	Cell Adhesion Hemopoiesis Viral Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Cell surface interactions at the vascular wall
Drugs		Farnesyl thiopyrophosphate
Diseases		Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Aspartate aminotransferase levels ( 29403010) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 24097068 18193043 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414)	Acne (severe) ( 24927181) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Conduct disorder (symptom count) ( 20585324)
Interacting Genes		4 interacting genes: EWSR1 POT1 RNF141 TERF1	14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN
Entrez ID		4598	6404
HPRD ID		02015	02845
Ensembl ID		ENSG00000110921	ENSG00000110876
Uniprot IDs		B2RDU6 B7Z301 F5H8H2 Q03426	Q14242
PDB IDs		2R3V	1G1S
Enriched GO Terms of Interacting Partners?
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