MVK and RNF141

Data Source:
BioGRID (two hybrid)

		MVK	RNF141
Description		mevalonate kinase	ring finger protein 141
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GO Annotations	Cellular Component	Peroxisome Cytosol Intracellular Membrane-bounded Organelle	Membrane
	Molecular Function	Magnesium Ion Binding Mevalonate Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Phosphorylation Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Inflammatory Response	Regulation Of Transcription, DNA-templated Protein Autoubiquitination
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Farnesyl thiopyrophosphate
Diseases		Mevalonate kinase deficiency; Hyperimmunoglobulinemia D; Mevalonic aciduria
GWAS		Aspartate aminotransferase levels ( 29403010) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 24097068 18193043 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Neutrophil count ( 29403010) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 28957414)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		4 interacting genes: EWSR1 POT1 RNF141 TERF1	7 interacting genes: DTX3 MAP3K1 MVK PLK3 SMURF1 TRIM24 TRIM8
Entrez ID		4598	50862
HPRD ID		02015	11509
Ensembl ID		ENSG00000110921	ENSG00000110315
Uniprot IDs		B2RDU6 B7Z301 F5H8H2 Q03426	Q8WVD5
PDB IDs		2R3V	2ECN 5XEK
Enriched GO Terms of Interacting Partners?
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